Overview of MOTS-c Peptide
MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a 16‑amino acid peptide encoded within the mitochondrial genome. Discovered in 2015, it has attracted considerable attention in the life sciences because it appears to participate in metabolic regulation through AMP‑activated protein kinase (AMPK) pathways and folate cycle modulation. In laboratory settings, synthetic MOTS-c is produced via solid‑phase peptide synthesis (SPPS) and purified to high standards, enabling reproducible experimentation.
Investigators use MOTS-c in cell‑based assays and animal models to examine how mitochondria‑derived signaling molecules influence glucose and lipid metabolism, insulin sensitivity, and cellular stress responses. Because the peptide is known to translocate to the nucleus and alter gene expression under metabolic challenge, it serves as a valuable tool for mapping inter‑organelle communication. All studies remain strictly confined to bench research; MOTS-c is not approved for any human or veterinary diagnostic, therapeutic, or prophylactic application.
The growing interest in mitochondrial‑derived peptides has driven demand for large quantities of high‑purity research material. For groups planning extended study timelines or comparative dose‑response investigations, the decision to buy MOTS‑c bulk wholesale offers practical and economic advantages. Obtaining a single synthesis lot eliminates inter‑batch variation, while per‑miligram cost reductions free up funds for additional reagents and analytical services.
Benefits of Bulk Wholesale Purchasing
Procuring research peptides in larger amounts aligns with the needs of academic core facilities, contract research organizations, and pharmaceutical discovery teams. The advantages go beyond simple price breaks; they directly support the reproducibility and logistical efficiency that rigorous experimental design demands.
Cost Efficiency for Research Programs
When you buy MOTS‑c bulk wholesale, the cost per milligram typically falls well below what standard catalog sizes cost. For a study consuming tens of milligrams per week – for example, a multi‑arm animal investigation with daily administrations over several months – the cumulative savings can be substantial. These savings can be redirected toward complementary assays, transcriptomic analyses, or expanded sample sizes, enhancing the statistical power of the work. Many suppliers further offer tiered pricing that reduces the unit price as the order quantity increases, making it worthwhile to forecast annual consumption and place a single bulk order rather than multiple small purchases.
Consistent Batch Quality
Inter‑batch variability, even when each lot meets the same purity specification, can introduce subtle differences in solubility, aggregation propensity, or bioactivity. By obtaining a single large batch for an entire research program, teams eliminate this variable. A bulk lot is manufactured under a single set of conditions, characterized once, and then aliquoted as needed. Each aliquot therefore behaves identically in downstream assays. Reputable manufacturers subject the bulk material to thorough analytical characterization – including high‑performance liquid chromatography (HPLC) and mass spectrometry (MS) – and retain a reference sample for future verification. This level of control is especially important for longitudinal studies that may span several years.
Quality Specifications for Research-Grade MOTS-c
When sourcing MOTS‑c for laboratory investigations, verifying the analytical data is essential. Established specifications for research‑grade material typically include:
- Reinheit ≥95% as determined by reversed‑phase HPLC at 214 nm. A single, symmetrical peak and the absence of uncharacterized shoulders confirm the preparation meets the acceptance criterion.
- Molecular weight confirmation by electrospray ionization mass spectrometry (ESI‑MS) or matrix‑assisted laser desorption/ionization (MALDI‑MS). The observed mass should match the theoretical monoisotopic mass of 2,174.6 Da for the C‑terminally amidated peptide, within instrument tolerance.
- Endotoxin content <1 EU/mg, measured by the Limulus amebocyte lysate (LAL) assay. Low endotoxin levels are critical for in vivo studies to avoid confounding immune responses.
- Physical form: lyophilized (freeze‑dried) powder, white to off‑white in appearance. The peptide is typically provided as a trifluoroacetate salt, reflecting the cleavage conditions of SPPS; acetate or hydrochloride salt forms can be requested for specific applications.
- Solubility profile: the supplier should report whether the peptide dissolves freely in water, phosphate‑buffered saline (PBS), or requires a small amount of organic co‑solvent (e.g., <2% dimethyl sulfoxide), based on internal testing.
Researchers intending to buy MOTS‑c bulk wholesale can request that a sample from the prospective lot be shipped for in‑house qualification before the full quantity is released. Many manufacturers will provide a pre‑shipment sample at no additional charge, allowing the receiving laboratory to run its own HPLC trace, solubility test, or cell‑based activity assay.
Storage and Handling Guidelines
To preserve structural integrity and biological activity, lyophilized MOTS‑c should be stored at -20 °C in a desiccated environment, protected from light. The shelf life under these conditions is typically 24 months from the date of manufacture, though individual certificates of analysis will state the assigned retest date.
Once reconstituted, the peptide solution is less stable. It is advisable to aliquot the stock into single‑use volumes and store them at -20 °C or -80 °C, depending on the buffer composition. Repeated freeze‑thaw cycles should be avoided because they can promote aggregation and loss of activity. If the peptide must be kept in solution at 4 °C for a short‑term experiment, use sterile phosphate‑buffered saline (pH 7.4) and consume within one week.
- Reconstitution: Bring the lyophilized powder to room temperature before opening the vial to prevent condensation. Add sterile water for injection or PBS to the desired concentration, gently swirl (do not vortex), and allow the peptide to dissolve completely.
- Filtration: For sterile applications, pass the reconstituted solution through a 0.22 µm low‑protein‑binding filter.
- Dokumentation: Each aliquot label should include the date of reconstitution, concentration, and lot number for traceability.
How to Order MOTS-c Bulk Wholesale
The process for placing a wholesale order is straightforward, but because quantities are larger, buyers should plan for manufacturing lead times and shipping logistics. Suppliers that specialize in research‑grade peptides typically offer the following pathway.
Minimum Order Quantities
The standard minimum order quantity (MOQ) to buy MOTS‑c bulk wholesale is 1 gram. This threshold balances manufacturing efficiency with the needs of most research groups. For laboratories that anticipate consuming more than 10 grams over a fiscal year, further price reductions can be negotiated. Quantities exceeding 50 grams may require a dedicated synthesis run and a slightly longer lead time. Custom fill weights – for instance, pre‑aliquoted vials of 100 mg each – are often available on request, streamlining distribution within a multi‑site study.
Lead Times and Shipping
Once the purchase order is confirmed and any required export/import documentation (such as a signed end‑user statement) is processed, the typical manufacturing and quality‑control release cycle is 5–7 business days. During this period, the peptide is synthesized, cleaved, purified by preparative HPLC, lyophilized, and subjected to the full analytical panel. The finished product is then packed in pharmaceutical‑grade glass vials under an inert argon or nitrogen atmosphere.
Shipment is executed with validated cold‑chain packaging. Lyophilized peptides are placed in insulated containers with gel ice packs that maintain 2–8 °C in transit; for longer journeys, dry ice is used. Temperature loggers can be included to verify that the material was not exposed to excursion temperatures. Domestic shipments generally arrive within 1–3 business days after dispatch, while international orders clear customs within 3–5 business days, depending on the destination country’s regulations. Expedited shipping options (e.g., next‑day air) are available for urgent research requirements.
Häufig gestellte Fragen
Is MOTS-c suitable for in vivo research?
MOTS-c is widely referenced in peer‑reviewed literature describing rodent studies that examine metabolic regulation, exercise capacity, and nutrient sensing. When used in laboratory animals, the peptide must be handled in accordance with institutional animal care and use committee (IACUC) protocols or equivalent ethical review board approvals. Researchers should verify the endotoxin specification (<1 EU/mg), choose a pyrogen‑free vehicle, and confirm stability in that vehicle prior to commencing the study. Any in vivo work is performed strictly within the scope of non‑clinical research and must not be interpreted as a model for human application.
What documentation accompanies bulk orders?
Every bulk shipment of MOTS‑c is accompanied by a comprehensive data package that includes:
- Analysezertifikat (CoA): reports the lot number, date of manufacture, retest date, HPLC purity (chromatogram), MS spectrum, peptide content (net weight), residual counter‑ion content, and endotoxin result.
- Material Safety Data Sheet (MSDS/SDS): outlines physical and chemical properties, handling precautions, first‑aid measures, and disposal recommendations per OSHA or GHS formatting.
- Solubility and storage guidelines: a supplementary document summarizing the supplier’s recommended reconstitution protocol and stability data.
For customs clearance, the commercial invoice and airway bill will clearly state “Laboratory Research Peptide – Not for Human or Veterinary Use.” End‑user declarations can be drafted upon request to satisfy importation requirements.
Contact Our Team for Bulk Pricing
To receive a personalized quotation for your planned purchase, please submit a request through the contact form on our website. Provide the desired quantity, any special requirements (e.g., salt form, custom aliquoting), and your shipping destination. A dedicated account manager, familiar with the procurement workflows of research institutions and pharmaceutical distributors, will respond within 24 business hours.
Hinweis: Nur für Forschungszwecke: All products mentioned are intended solely for laboratory research applications. They are not manufactured, tested, or labeled for human or veterinary diagnostic, therapeutic, or prophylactic purposes. Use of these materials should comply with all applicable laws and institutional guidelines.
Nur für Forschungszwecke. Nicht zur Anwendung am Menschen oder bei Tieren bestimmt.
