{"id":1506,"date":"2026-06-30T15:28:54","date_gmt":"2026-06-30T15:28:54","guid":{"rendered":"https:\/\/gemaihealth.com\/?p=1506"},"modified":"2026-06-30T15:28:54","modified_gmt":"2026-06-30T15:28:54","slug":"bremelanotid-pulver-in-grosmengen-fur-forschungszwecke","status":"publish","type":"post","link":"https:\/\/gemaihealth.com\/de\/bremelanotide-bulk-powder-for-research\/","title":{"rendered":"Bremelanotid-Pulver in Gro\u00dfmengen f\u00fcr Forschungszwecke"},"content":{"rendered":"<h2>Introduction to Bremelanotide Bulk Powder<\/h2>\n<p>\nBremelanotide is a synthetic cyclic heptapeptide designed as a potent and selective agonist of the melanocortin 4 receptor (MC4R). Derived from the endogenous melanocortin peptide \u03b1\u2011MSH, its primary sequence is Ac\u2011Nle\u2011cyclo[Asp\u2011His\u2011D\u2011Phe\u2011Arg\u2011Trp\u2011Lys]\u2011OH, with the cycle formed via a lactam bridge between the side chains of aspartic acid and lysine. This structural modification enhances metabolic stability and receptor selectivity compared to linear analogs. Bremelanotide bulk powder is supplied exclusively for laboratory research applications, offering the research community a well-characterized tool to explore melanocortin receptor biology.\n<\/p>\n<p>\nResearch on MC4R signaling has grown steadily since the receptor was identified as a key component in central neuroendocrine pathways and energy homeostasis in preclinical models. Bremelanotide\u2019s high affinity and agonistic properties at MC4R make it a reference compound for in vitro pharmacological profiling, enabling scientists to dissect receptor binding, second\u2011messenger activation, and intracellular trafficking. All products sold under this offering are strictly for research use; they are not prepared, tested, or authorized for any human or veterinary administration, clinical investigation, or diagnostic procedure.\n<\/p>\n<h2>Chemical and Physical Properties<\/h2>\n<p>\nBremelanotide bulk powder (CAS 189691\u201106\u20113) is provided as a white to off\u2011white lyophilized solid with the following defined characteristics:\n<\/p>\n<ul>\n<li><strong>Molecular formula:<\/strong> C<sub>50<\/sub>H<sub>68<\/sub>N<sub>14<\/sub>O<sub>10<\/sub><\/li>\n<li><strong>Molecular weight:<\/strong> 1025.18 g\/mol (anhydrous basis)<\/li>\n<li><strong>Appearance:<\/strong> Free\u2011flowing, white to faintly cream-colored powder after lyophilization from aqueous solution<\/li>\n<li><strong>Purity standard:<\/strong> \u226598% by reverse\u2011phase HPLC, with many lots meeting &gt;99% area purity. Purity is determined by integration of the main peak relative to total peak area at 214 nm.<\/li>\n<\/ul>\n<p>\nThe peptide demonstrates good solubility in polar organic solvents such as dimethyl sulfoxide (DMSO) at concentrations exceeding 50 mg\/mL. For aqueous experiments, stock solutions can be prepared at 1\u20132 mg\/mL in sterile phosphate\u2011buffered saline or other buffered systems, often with gentle agitation and brief warming to 37 \u00b0C. Researchers should verify solubility in their specific assay media and avoid prolonged exposure to alkaline conditions that could promote racemization or hydrolysis.\n<\/p>\n<p>\nIdentity is routinely confirmed by electrospray ionization mass spectrometry (ESI\u2011MS), yielding a prominent [M+2H]<sup>2+<\/sup> ion corresponding to the calculated mass. Peptide content is measured by quantitative amino acid analysis to correct for residual moisture and counterions. The product is supplied as a lyophilized powder that should be stored under the recommended conditions to maintain integrity.\n<\/p>\n<h2>Research Applications<\/h2>\n<p>\nThe primary research utility of Bremelanotide bulk powder lies in its ability to selectively activate MC4R in controlled in vitro environments. Because the melanocortin receptor family (MC1R through MC5R) mediates diverse physiological signals, researchers employ Bremelanotide to investigate the specific contribution of MC4R to cellular signaling cascades. Common applications include:\n<\/p>\n<ul>\n<li><strong>Receptor\u2011binding assays:<\/strong> Competitive displacement of radiolabeled ligands (such as [<sup>125<\/sup>I]\u2011NDP\u2011\u03b1\u2011MSH) from membranes of cells heterologously expressing MC4R. Bremelanotide typically exhibits low nanomolar binding affinity (K<sub>i<\/sub>), providing a benchmark for evaluating novel ligands.<\/li>\n<li><strong>Second\u2011messenger assays:<\/strong> Measurement of cAMP accumulation in MC4R\u2011transfected cell lines (e.g., HEK293, CHO\u2011K1) after exposure to the peptide. Functional data give EC<sub>50<\/sub> values in the sub\u2011nanomolar to low nanomolar range, depending on the expression system and assay conditions.<\/li>\n<li><strong>Calcium mobilization studies:<\/strong> Fluorescent dye\u2011based (for example, Fluo\u20114) detection of intracellular Ca<sup>2+<\/sup> release, exploring the engagement of G<sub>q<\/sub>\u2011coupled pathways alongside the canonical G<sub>s<\/sub> pathway.<\/li>\n<li><strong>Biased signaling analyses:<\/strong> Profiling of arrestin recruitment, receptor internalization, and mitogen\u2011activated protein kinase (MAPK) activation to delineate ligand\u2011directed signaling modalities.<\/li>\n<li><strong>Pharmacological comparisons:<\/strong> As a reference agonist, Bremelanotide helps characterize new synthetic melanocortin peptides and small molecules in head\u2011to\u2011head experiments.<\/li>\n<\/ul>\n<p>\nAll of these applications are confined to laboratory\u2011scale research. The compound is not intended, qualified, or approved for any human or veterinary application, diagnostic use, or clinical study. Researchers should design experiments solely for investigational purposes and operate in accordance with institutional biosafety requirements.\n<\/p>\n<h3>Mechanism of Action in Research Contexts<\/h3>\n<p>\nAt the molecular level, Bremelanotide acts as a high\u2011affinity ligand for MC4R, a class A G\u2011protein\u2011coupled receptor predominantly coupled to the stimulatory G protein G<sub>\u03b1s<\/sub>. Binding of the peptide induces a conformational change that promotes guanine nucleotide exchange on G<sub>\u03b1s<\/sub>, activating adenylyl cyclase and elevating intracellular cyclic adenosine monophosphate (cAMP). This cascade subsequently triggers protein kinase A (PKA) activation and phosphorylation of downstream targets. In multiple cell lines expressing recombinant MC4R, Bremelanotide elicits robust cAMP responses with reported EC<sub>50<\/sub> values typically between 0.5 and 2.0 nM.\n<\/p>\n<p>\nIn addition to the G<sub>s<\/sub>\u2011mediated pathway, Bremelanotide can stimulate calcium flux in certain cellular backgrounds. This effect arises from coupling of MC4R to G<sub>q\/11<\/sub> proteins, leading to phospholipase C\u2011\u03b2 activation, inositol trisphosphate generation, and release of calcium from intracellular stores. The relative balance of G<sub>s<\/sub> versus G<sub>q<\/sub> activation is an active area of investigation, as it may reflect ligand\u2011biased signaling at the MC4R. The peptide\u2019s activity is highly selective: in vitro binding and functional assays show that Bremelanotide has &gt;100\u2011fold selectivity for MC4R over the closely related MC1R and MC5R subtypes, with negligible activation of MC2R and modest activity at MC3R. Such pharmacological fingerprinting helps researchers dissect the roles of individual melanocortin receptors in complex biological models.\n<\/p>\n<h2>Product Specifications and Quality Control<\/h2>\n<p>\nBremelanotide bulk powder is manufactured under rigorous quality management systems suitable for research\u2011grade reagents. Each production batch undergoes a suite of analytical tests to verify identity, purity, and physical characteristics. The following specification points are typical for the product:\n<\/p>\n<ul>\n<li><strong>HPLC purity:<\/strong> \u226598%. The chromatogram shows a single dominant peak with retention time consistent with the reference standard. Trace impurities are individually &lt;1.0%.<\/li>\n<li><strong>Mass spectrometry:<\/strong> Observed mass consistent with theoretical molecular weight (within \u00b10.5 Da). The ESI\u2011MS spectrum provides the expected multiply\u2011charged ion envelope.<\/li>\n<li><strong>Peptide content:<\/strong> Determined by amino acid analysis or nitrogen determination, reported as net peptide weight per total product weight. Typical content &gt;80%\u201385%, with the balance comprised of residual water and counterions.<\/li>\n<li><strong>Solubility confirmation:<\/strong> A sample of the batch is dissolved in DMSO or aqueous buffer at a defined concentration to ensure complete dissolution without particulate matter.<\/li>\n<li><strong>Appearance:<\/strong> White to off\u2011white powder without discoloration or clumping.<\/li>\n<\/ul>\n<p>\nA Certificate of Analysis (CoA) accompanies each shipment, summarizing the actual results for the specific lot. Additional quality controls, such as endotoxin testing (acceptable limit &lt;1.0 EU\/mg upon request), residual solvent analysis, and trifluoroacetic acid content, can be performed for special orders. Long\u2011term stability under recommended storage conditions is supported by real\u2011time and accelerated aging studies; the product retains \u226597% purity for at least 24 months when stored according to the guidelines. Researchers should aliquot and store the material appropriately after initial opening to prevent repeated freeze\u2011thaw cycles that may accelerate degradation.\n<\/p>\n<h2>Packaging and Storage Guidelines<\/h2>\n<p>\nBremelanotide bulk powder is dispensed into sealed, inert containers chosen to maintain peptide integrity during shipment and long\u2011term storage. For research quantities up to 10 grams, the standard container is a clear borosilicate glass vial with a PTFE\u2011lined screw cap, backfilled with dry argon or nitrogen to displace oxygen and moisture. Multi\u2011gram bulk orders may be packaged in high\u2011density polyethylene (HDPE) bottles with a desiccant pouch, further protected inside a secondary aluminum\u2011foil barrier bag. All containers bear a label with product name, lot number, net weight, and storage instructions.\n<\/p>\n<p>\nRecommended storage conditions are as follows:\n<\/p>\n<ul>\n<li><strong>Temperature:<\/strong> \u201320 \u00b0C (\u00b15 \u00b0C) in a non\u2011frost\u2011free freezer. Brief excursions during shipment at ambient temperature are acceptable provided the material is promptly placed at \u201320 \u00b0C upon receipt.<\/li>\n<li><strong>Humidity control:<\/strong> Keep the container tightly closed and desiccated. Exposure to ambient moisture can lead to peptide aggregation and loss of solubility.<\/li>\n<li><strong>Light protection:<\/strong> Store in the original opaque secondary packaging or wrap the container in aluminum foil to prevent photodegradation.<\/li>\n<\/ul>\n<p>\nUnder these conditions, the shelf life is 24 months from the date of manufacture. After reconstitution in a solvent, solutions should be used immediately or aliquoted into single\u2011use volumes and stored at \u201320 \u00b0C. Avoid repeated freeze\u2011thaw cycles, as they can cause precipitation and reduced biological activity. Laboratory personnel handling Bremelanotide powder or solutions should wear appropriate personal protective equipment, including nitrile gloves, safety goggles, and a lab coat. Weighing and dissolution procedures should be performed in a fume hood or biosafety cabinet to minimize aerosol inhalation and cross\u2011contamination. Spills should be cleaned immediately following institutional chemical hygiene protocols.\n<\/p>\n<h2>Ordering Information<\/h2>\n<p>\nBremelanotide bulk powder is offered to qualified research institutions, pharmaceutical companies, and authorized distributors. The standard minimum order quantity is 1 gram, though smaller sample amounts may be available for preliminary method development on a case\u2011by\u2011case basis. Larger scale requirements (tens to hundreds of grams or kilograms) can be accommodated through custom synthesis runs, providing batch\u2011to\u2011batch consistency essential for multi\u2011phase research programs.\n<\/p>\n<p>\nTypical lead time from confirmation of order to dispatch is 5 to 10 business days for quantities up to 100 grams. Larger orders or those requiring additional quality tests may extend the lead time slightly; an estimated production schedule is communicated at the time of quotation.\n<\/p>\n<p>\nResearchers can request custom specifications, such as purity higher than 99% by HPLC, defined counterion (e.g., acetate instead of trifluoroacetate), or packaging suitable for automated dispensing systems. All custom requests are subject to a feasibility assessment. For pricing, bulk discounts, and lot reservations, interested parties should contact the sales department with the required quantity, desired purity, and any specific analytical deliverables beyond the standard CoA. The supplier does not distribute Bremelanotide for any purpose that would involve administration to humans or animals; all inquiries must confirm that the intended use is solely for laboratory research.\n<\/p>\n<h3>Regulatory and Compliance Notes<\/h3>\n<p>\nThis Bremelanotide bulk powder is produced as a research chemical and is explicitly labeled \u201cFor Research Use Only. Not for Human or Veterinary Use.\u201d It has not been evaluated by any regulatory authority for use as a pharmaceutical ingredient, medical device component, or diagnostic reagent. No representation is made regarding its performance in clinical applications, its ability to detect any physiological condition, or its safety when administered to living organisms. The product is intended exclusively for in vitro experiments performed by trained technical staff within properly equipped laboratories.\n<\/p>\n<p>\nPurchasers are expected to be familiar with and comply with all applicable local, national, and international regulations governing the import, storage, handling, and disposal of research peptides. This includes adherence to guidelines on occupational safety, controlled substances, and dual\u2011use materials where relevant. The supplier will not knowingly sell this compound to individuals or organizations that intend to use it for non\u2011research purposes. Any deviation from the stated research\u2011use restriction constitutes a breach of the terms of sale and may void the warranty and liability protections. Shipments are accompanied by a safety data sheet (SDS) outlining proper handling and emergency procedures.\n<\/p>\n<p>\n<strong>Research use only:<\/strong> This product is intended strictly for in vitro laboratory research. It is not for use in humans, animals, or any clinical, diagnostic, or interventional procedure. Researchers must handle it in accordance with institutional safety guidelines and relevant regulatory requirements. No therapeutic claims, clinical performance assertions, or medical applications are associated with this chemical.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Introduction to Bremelanotide Bulk Powder Bremelanotide is a synthetic cyclic heptapeptide designed as a potent and selective agonist of the melanocortin 4 receptor (MC4R). Derived from the endogenous melanocortin peptide \u03b1\u2011MSH, its primary sequence is Ac\u2011Nle\u2011cyclo[Asp\u2011His\u2011D\u2011Phe\u2011Arg\u2011Trp\u2011Lys]\u2011OH, with the cycle formed via a lactam bridge between the side chains of aspartic acid and lysine. This structural [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1507,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"news_category":[],"class_list":["post-1506","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.6 (Yoast SEO v27.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Bremelanotide Bulk Powder for Research | Supplier<\/title>\n<meta name=\"description\" content=\"Procure high-purity Bremelanotide bulk powder for research. Strictly for in vitro laboratory studies. 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Ausschlie\u00dflich f\u00fcr In-vitro-Laboruntersuchungen bestimmt. Kontaktieren Sie uns f\u00fcr Gro\u00dfhandelspreise.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/gemaihealth.com\/de\/bremelanotid-pulver-in-grosmengen-fur-forschungszwecke\/","og_locale":"de_DE","og_type":"article","og_title":"Bremelanotide Bulk Powder for Research Applications","og_description":"Procure high-purity Bremelanotide bulk powder for research. Strictly for in vitro laboratory studies. 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