CJC-1295 DAC is a synthetic peptide analog of growth hormone-releasing hormone (GHRH). The laboratory compound is engineered with a Drug Affinity Complex (DAC) moiety, which permits covalent attachment to serum albumin within research models. This modification markedly extends the peptide\u2019s observable half-life, enabling sustained activation of the GHRH receptor in controlled experiments. Researchers utilize CJC-1295 DAC to investigate the pulsatile release of growth hormone (GH) and subsequent downstream secretion of insulin-like growth factor\u20111 (IGF\u20111). All raw material offered is strictly for laboratory research use; it is not intended for application in humans or animals, nor for diagnostic or clinical purposes.<\/p>\n
As a GHRH analog, CJC-1295 DAC retains the biologically active N\u2011terminal 29\u2011amino acid sequence of endogenous GHRH, with four strategic substitutions to improve resistance to enzymatic degradation. The DAC component consists of a maleimidopropionic acid linker conjugated to a lysine residue, which selectively reacts with the thiol group of cysteine\u201134 on circulating albumin. This conjugation effectively creates a stable peptide\u2011albumin adduct in vitro and in vivo, a property widely exploited in pharmacological research to study prolonged GHRH receptor engagement. Laboratories seeking high\u2011purity CJC-1295 DAC raw material for sale<\/strong> can rely on rigorously characterized batches suitable for repeatable and reproducible experimentation.<\/p>\n Each batch of CJC-1295 DAC raw material is subjected to comprehensive analytical testing to ensure consistency and reliability for research protocols. The chemical composition is a GHRH analog peptide covalently linked to the DAC moiety. The full molecular formula and amino acid sequence are provided in the certificate of analysis accompanying each order; researchers may request this documentation from our technical support team. The product is manufactured under controlled conditions and is not exposed to non\u2011laboratory substances during synthesis or purification.<\/p>\n The peptide\u2011DAC conjugate has a molecular weight of approximately 4000 Daltons. It is readily soluble in distilled water or sterile buffers such as phosphate\u2011buffered saline (PBS) at concentrations typically employed in bench research. The lyophilized powder demonstrates robust stability when stored under recommended conditions; repeated freeze\u2011thaw cycles of the lyophilized powder or reconstituted solution can degrade the peptide and should be avoided. Researchers often prepare single\u2011use aliquots of reconstituted material to preserve structural integrity. The DAC\u2011albumin binding reaction occurs rapidly in aqueous solutions, and binding characteristics can be studied via size\u2011exclusion chromatography or mass spectrometry.<\/p>\n CJC-1295 DAC is widely applied in basic and translational laboratory investigations. Its principal utility lies in clarifying the mechanisms governing growth hormone release and the GH\/IGF\u20111 axis. Because the DAC modification prolongs receptor activation, it serves as a tool for studying sustained endocrine signaling in vitro and in animal models. Researchers may administer the peptide in conjunction with receptor antagonists or signaling inhibitors to dissect intracellular pathways in pituitary somatotrophs or other GH\u2011responsive cells.<\/p>\n The compound is not intended for any diagnostic application, nor may it be used in procedures that directly or indirectly involve human or veterinary subjects outside of strictly controlled laboratory environments.<\/p>\n Proper storage and handling are critical to maintaining the integrity of CJC-1295 DAC raw material. Lyophilized vials should be kept in a freezer at \u221220 \u00b0C, protected from light and moisture. Unopened vials stored under these conditions remain stable through the expiration date indicated on the label. After removal from cold storage, allow the vial to reach ambient temperature before opening to prevent condensation.<\/p>\n Reconstitution should be performed with sterile, research\u2011grade water or buffer. The resulting solution is intended for immediate laboratory use. Due to the absence of preservatives, any unused portion after a single experiment must be discarded. Avoid vortexing vigorously; gentle agitation or swirling is sufficient to achieve dissolution. Do not store reconstituted peptide for later use, as degradation and microbial contamination can occur even under refrigeration.<\/p>\n We supply CJC-1295 DAC raw material in a range of standard pack sizes to accommodate diverse research requirements. All products are presented in sterile, borosilicate glass vials sealed with bromobutyl rubber stoppers and aluminum flip\u2011off caps for integrity during transit.<\/p>\n For large\u2011scale orders placed by research institutions or distribution partners, custom packaging configurations can be arranged. Each vial is labelled with the product name, lot number, net weight, and storage instructions. Certificates of analysis are included with every shipment, documenting purity, water content, and endotoxin levels.<\/p>\n To obtain current pricing, stock availability, or to request a sample for evaluation, please contact our dedicated sales team. We serve a global client base that includes university laboratories, pharmaceutical companies, and licensed distributors. Bulk discount structures are available for qualifying institutions and repeat orders. Orders are typically processed within 5\u20137 business days, with dispatch confirmation and tracking details provided upon shipment. For international deliveries, temperature\u2011controlled packaging (validated cold\u2011chain shipping) is employed to maintain product stability during transit. Please note that all sales are subject to our standard terms and conditions, which require verification of the buyer\u2019s research\u2011related credentials.<\/p>\n Below are answers to common inquiries from researchers considering the acquisition of CJC-1295 DAC raw material. For further technical questions, our scientific support team can be reached via the contact information provided with your quotation.<\/p>\n CJC-1295 (often referred to as \u201cCJC-1295 without DAC\u201d or Mod GRF 1\u201129) is the core 29\u2011amino acid GHRH analog bearing four substitutions that impart resistance to rapid proteolytic cleavage. It has a relatively short plasma half\u2011life in research models, typically less than 30 minutes. CJC-1295 DAC incorporates the same peptide sequence but is additionally functionalized with a maleimidopropionic acid linker that covalently attaches to free cysteine residues of serum albumin. In laboratory settings, this DAC modification substantially prolongs the apparent half\u2011life to hours or days, allowing less frequent administration in animal study designs. This distinction is essential for investigators selecting the appropriate tool for their experimental paradigm.<\/p>\n This product is manufactured for laboratory research only. It is not approved for use in humans, animals, or as a component of any drug, medicine, dietary supplement, or food. Under no circumstances should CJC-1295 DAC raw material be administered outside of a controlled in vitro or in vivo research environment. Our supply agreement strictly prohibits any attempt to repurpose the material for unintended applications.<\/p>\n For experimental protocols, researchers typically reconstitute the lyophilized peptide in sterile, high\u2011purity water or a compatible buffer. The volume added determines the final concentration required for the specific study. After reconstitution, the solution should be used immediately and any remainder discarded. Proper aseptic technique must be observed throughout to avoid contamination of cell cultures or animal models.<\/p>\n Every lot of CJC-1295 DAC raw material undergoes HPLC analysis to confirm purity of \u226598%. In addition, mass spectrometry (ESI\u2011MS or MALDI\u2011TOF) verifies molecular weight, and residual counter\u2011ion content is monitored. The certificate of analysis provided with your order includes batch\u2011specific results for purity, water content, and endotoxin level. Should any parcel arrive with visible damage, we offer a replacement policy contingent upon timely notification and photographic evidence.<\/p>\n Disclaimer: CJC-1295 DAC raw material is sold strictly for in vitro and in vivo laboratory research use only. It is not intended for human or veterinary application, nor for any diagnostic, therapeutic, or clinical purpose. Purchasers are responsible for compliance with all applicable local, national, and international regulations governing research chemicals.<\/em><\/p>\n Nur f\u00fcr Forschungszwecke. Nicht zur Anwendung am Menschen oder bei Tieren bestimmt.<\/em><\/p>","protected":false},"excerpt":{"rendered":" Introduction to CJC-1295 DAC Raw Material CJC-1295 DAC is a synthetic peptide analog of growth hormone-releasing hormone (GHRH). The laboratory compound is engineered with a Drug Affinity Complex (DAC) moiety, which permits covalent attachment to serum albumin within research models. This modification markedly extends the peptide\u2019s observable half-life, enabling sustained activation of the GHRH receptor […]<\/p>\n","protected":false},"author":1,"featured_media":1782,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"news_category":[],"class_list":["post-1781","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"\nProduktspezifikationen<\/h2>\n
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Chemical Properties<\/h3>\n
Forschungsanwendungen<\/h2>\n
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Storage and Handling<\/h2>\n
Packaging Options<\/h2>\n
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Bestellinformationen<\/h2>\n
H\u00e4ufig gestellte Fragen<\/h2>\n
Difference Between CJC-1295 and CJC-1295 DAC<\/h3>\n
Human Use Clarification<\/h3>\n
Reconstitution Guidance for Research<\/h3>\n
Purity Guarantee<\/h3>\n