埃皮他隆（Epitalon）

产品概览

Epithalon (also Epitalon or Epithalone) consists of four amino acids — alanine, glutamic acid, aspartic acid, and glycine — working together to influence telomerase activity. First identified as the active fragment of epithalamin, Epithalon was found in physiological pineal gland extract in 2017. It functions at the molecular level, addressing the aging process from within through telomere maintenance and melatonin regulation.

作用机制

Epithalon operates through two primary mechanisms: (1) It reactivates telomerase by upregulating hTERT mRNA expression, enabling telomere lengthening and allowing cells to surpass the Hayflick limit; (2) It stimulates the pineal gland to restore endogenous melatonin production, normalizing circadian rhythm function that naturally declines with age.

主要优势

Anti-Aging at the Cellular Level — Reactivates telomerase in human cells, producing dose-dependent telomere lengthening. Treated fibroblasts surpass the Hayflick limit (>44 passages) while retaining youthful morphology and gene expression. Enables genuine cellular youth preservation.

Circadian Rhythm Regulation — Restores disrupted circadian rhythms in elderly individuals by normalizing nighttime melatonin release. Modulates pineal gland function without side effects, addressing sleep disorders and circadian disruption.

Sleep & Brain Health — Enhances sleep quality through sustained melatonin production. Melatonin's antioxidant properties protect the brain from oxidative stress, optimizing sleep architecture and supporting natural brain defenses.

DNA Protection & Repair — Reduces DNA damage levels through antioxidant properties. Prevents decline in key enzyme synthesis under hypoxic conditions. Increases phosphorylated CREB levels for gene expression regulation and cell survival.

参考资料

1. Khavinson VK, et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. *Bull Exp Biol Med.* 2003;135(6):590–592.
2. Khavinson VK, et al. Peptide bioregulators: The new class of geroprotectors. *Advances in Gerontology.* 2011;26(1):20–37.
3. Chitimus DM, et al. Melatonin's impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease. *Biomolecules.* 2020;10(9):1211.