CJC-1295 DAC (Drug Affinity Complex) is a synthetic analogue of the endogenous growth hormone\u2013releasing hormone (GHRH) that has been modified to include a reactive maleimidopropionic acid group conjugated to a lysine residue. This structural modification allows the peptide to form a stable covalent bond with circulating albumin after administration in preclinical models, resulting in a significantly prolonged half\u2011life compared to unmodified GHRH analogues. In laboratory research, CJC-1295 DAC is primarily employed to investigate the pulsatile nature of growth hormone (GH) secretion, the regulation of insulin-like growth factor 1 (IGF-1), and broader metabolic pathways in cell-based assays and animal models. Its amino acid sequence is derived from the first 29 residues of GHRH, with four amino acid substitutions (Tyr\u00b9, Ala\u00b2, Gln\u2078, Ala\u00b9\u2075) that enhance stability and receptor binding in experimental settings.<\/p>\n
For procurement officers, laboratory managers, and institutional distributors, understanding the wholesale price per gram of CJC-1295 DAC is a critical component of budget planning. Wholesale pricing for research-grade lyophilized powder is not fixed; it reflects a complex interplay of purity, net peptide content, order volume, and supplier-specific costs. Typical price ranges for a single gram of high-purity CJC-1295 DAC in the wholesale market can span from approximately USD 2,500 to over USD 15,000, though figures outside this band are possible depending on the specifications and the geographic region. This wide interval underscores the importance of evaluating the complete product profile rather than solely comparing headline figures. Researchers and bulk resellers are advised to request detailed quotes that separate the cost of the active peptide from fillers and to confirm that pricing terms include all relevant documentation.<\/p>\n
The following sections dissect the primary variables that influence CJC-1295 DAC wholesale pricing and provide a framework for sourcing the peptide responsibly while maintaining strict compliance with its intended research-only application.<\/p>\n
The most significant cost driver is chromatographic purity, usually determined by reverse-phase high-performance liquid chromatography (HPLC) at 214 nm or 220 nm. Suppliers typically offer research-grade CJC-1295 DAC at purity thresholds of 95%, 98%, or >99%. A peptide advertised at >99% HPLC purity will command a substantially higher wholesale price per gram than the 95% grade, because achieving and verifying that level of purity demands additional purification steps, longer analysis time, and higher solvent consumption. Researchers should also distinguish between gross peptide weight and net peptide content. Lyophilized powders often contain residual water, trifluoroacetic acid (TFA) salts from synthesis, and acetate counter\u2011ions. The net peptide content, obtained via amino acid analysis or elemental nitrogen determination, can range from 70% to 90% of the total mass. A bulk lot with a 75% net content may appear cheaper on a per\u2011gram basis, but the actual cost per milligram of active peptide could be higher than a slightly more expensive lot with 88% content. Wholesale quotes should always clarify whether the price is based on gross weight or is adjusted for net peptide content.<\/p>\n
Wholesale pricing models for research peptides are heavily volume-dependent. Purchasing CJC-1295 DAC in single\u2011gram increments places the buyer in a different pricing tier compared to research organizations that place blanket orders for 10 g, 50 g, or more per annum. At the 10\u2011gram level, buyers can often expect a discount of 15\u201125% off the listed single\u2011gram price, while multi\u2011hundred\u2011gram contracts may lower the per\u2011gram cost by 40% or more, provided the same synthesis batch is used. Some manufacturers also apply tiered pricing that resets at pre\u2011defined quantity breaks (e.g., 1 g, 5 g, 25 g, 100 g). Institutional purchasing consortia and university procurement departments frequently negotiate framework agreements that lock in a fixed per\u2011gram price for a 12\u2011 or 24\u2011month period, insulating the laboratory from short\u2011term raw material price fluctuations. In all cases, the quoted wholesale price per gram should clearly state the minimum order quantity to which it applies.<\/p>\n
The geographic base of the manufacturer or distributor introduces both direct and indirect costs. Wholesale CJC-1295 DAC produced in regions with lower manufacturing overhead may carry a lower price per gram ex\u2011works, but international cold\u2011chain shipping, customs duties, and import taxes can erode that advantage. Lyophilized peptides are stable at ambient temperature for short periods, yet many researchers insist on refrigerated or frozen transport to preserve long\u2011term integrity, which adds a surcharge. A research institution in the European Union sourcing from a GMP\u2011compliant facility in Asia may face additional fees for a customs broker and for obtaining an EORI (Economic Operators Registration and Identification) number. Conversely, relying on a local distributor can reduce logistics expense but may involve a mark\u2011up of 10\u201130% on the underlying wholesale price. When comparing international offers, always request a landed\u2011cost breakdown that includes freight, insurance, import duty, and any applicable value\u2011added tax.<\/p>\n
The scope and depth of the analytical data package supplied with each lot directly influence the wholesale price. A basic certificate of analysis (CoA) may include only HPLC purity and mass spectrometry (MS) identification. Comprehensive quality control (QC) packages add tests such as: amino acid analysis (AAA) for net peptide content; counter\u2011ion quantification by ion chromatography; residual solvent analysis by gas chromatography; endotoxin testing (LAL assay) for < 0.1 EU\/mg; and bioburden or sterility data. Each additional assay represents a direct laboratory cost that the supplier recovers through a higher unit price. For large\u2011scale institutional orders intended for long\u2011running studies, investing in a more exhaustive QC dossier can reduce the risk of batch\u2011to\u2011batch variability and avoid costly experimental failures. Regulatory\u2011aligned documentation, such as a Drug Master File (DMF) reference or a Technical Package for a research peptide, can also add several hundred to a few thousand dollars to the overall order, although this cost is often amortized across larger volumes.<\/p>\n
Due diligence begins with verifying that a prospective supplier operates strictly within the research\u2011chemical space and maintains transparent business practices. Reliable sources typically:<\/p>\n
Before placing a large wholesale order, request a small evaluation sample (typically 1\u201110 mg) and have an independent third\u2011party laboratory verify the HPLC purity and molecular weight by mass spectrometry. This pre\u2011qualification step, while adding a short-term cost, can prevent significant financial loss from a full\u2011scale purchase that does not meet specification. Additionally, check whether the supplier is listed on any known industry watchlists or has unresolved complaints on professional forums frequented by peptide chemists and laboratory managers.<\/p>\n
Once a potential supplier is shortlisted, the next step is a rigorous review of the product specification sheet and the sample CoA. Key parameters to scrutinize include:<\/p>\n
For wholesale transactions, insist that the final batch\u2011specific CoA accompanies every order and matches the lot number printed on the vials. If the supplier uses sub\u2011batch filling, confirm that the analytical data correspond to the sub\u2011batch actually shipped.<\/p>\n
Institutional buyers often have leverage that individual laboratories lack. When requesting a wholesale quote for CJC-1295 DAC, present a consolidated forecast that aggregates demand from multiple research groups or departments. This approach can unlock volume discounts that would not be available to single\u2011lab orders. During negotiations, consider:<\/p>\n
All agreements should be documented in a formal purchase order that references the exact product code, purity, net content, accepted tolerance limits, and the mutually agreed analytical release specifications. Never finalize a wholesale peptide purchase without a signed material safety data sheet (MSDS) that confirms the substance is for research use only.<\/p>\n
There is no universally fixed price. For lyophilized powder with \u226598% HPLC purity and a documented net peptide content above 80%, the wholesale price per gram typically falls between USD 3,000 and USD 8,000 when ordered in quantities between 5 g and 25 g. Prices below USD 2,000 per gram should prompt careful scrutiny of the purity claim, net peptide content, and the completeness of the analytical data. Conversely, quotes exceeding USD 12,000 per gram usually reflect ultra\u2011high purity (>99.5%), full QC panels, or specialized packaging requirements. Researchers are advised to obtain at least three competitive quotes that are each supported by a detailed, lot\u2011specific CoA to establish a realistic benchmark.<\/p>\n
Bulk ordering shifts the cost structure in two ways. First, the direct synthesis costs for a single large batch are lower per gram than running multiple small syntheses, because the fixed costs of resin, solvents, and purification columns are spread over a greater mass. Second, many contract synthesis manufacturers apply a steep discount curve: the per\u2011gram price at the 10\u2011g point may be 20\u201330% lower than the 1\u2011g price, and at quantities above 100 g the per\u2011gram rate can drop to 50% or less of the single\u2011gram rate. However, the final landed price must account for any additional handling, such as lyophilization into multiple vials, specialised labelling, and enhanced quality control on each sub\u2011lot. It is always prudent to request a formal quotation that outlines the exact price at each quantity tier and includes all ancillary costs.<\/p>\n
For most in\u2011vitro and in\u2011vivo laboratory studies, a purity of \u226598% as measured by analytical HPLC is considered the standard for research\u2011grade CJC-1295 DAC. Peptides that pass the 99% threshold are available, but the incremental improvement may not translate to a meaningful difference in experimental outcomes for many protocols, making the cost premium difficult to justify. The specification that matters equally is the net peptide content; a lot with 99% chromatographic purity but a net content of only 72% will deliver less active peptide per weighed milligram than a 98% pure lot with 85% net content. Therefore, expect a certificate of analysis that explicitly reports both HPLC purity (peak area %) and net peptide content (weight %) from an orthogonal method such as amino acid analysis. Reputable wholesale suppliers will not hesitate to provide these values.<\/p>\n
\u4ec5\u9650\u7814\u7a76\u7528\u9014\u7684\u8bf4\u660e\uff1a<\/strong> CJC-1295 DAC is furnished exclusively as a laboratory reagent for scientific investigation. It is not intended for administration to humans or animals outside of approved research protocols, and it may not be used for any clinical, therapeutic, or diagnostic purpose. All handling and experimentation must comply with the applicable institutional and governmental regulations governing research chemicals.<\/p>\n \u4ec5\u9650\u7814\u7a76\u7528\u9014\u3002\u4e0d\u5f97\u7528\u4e8e\u4eba\u7c7b\u6216\u517d\u533b\u7528\u9014\u3002.<\/em><\/p>","protected":false},"excerpt":{"rendered":" Overview of CJC-1295 DAC for Research CJC-1295 DAC (Drug Affinity Complex) is a synthetic analogue of the endogenous growth hormone\u2013releasing hormone (GHRH) that has been modified to include a reactive maleimidopropionic acid group conjugated to a lysine residue. This structural modification allows the peptide to form a stable covalent bond with circulating albumin after administration […]<\/p>\n","protected":false},"author":1,"featured_media":1785,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"news_category":[],"class_list":["post-1784","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"\n