Introduction to CJC-1295 DAC Raw Material
CJC-1295 DAC is a synthetic peptide analog of growth hormone-releasing hormone (GHRH). The laboratory compound is engineered with a Drug Affinity Complex (DAC) moiety, which permits covalent attachment to serum albumin within research models. This modification markedly extends the peptide’s observable half-life, enabling sustained activation of the GHRH receptor in controlled experiments. Researchers utilize CJC-1295 DAC to investigate the pulsatile release of growth hormone (GH) and subsequent downstream secretion of insulin-like growth factor‑1 (IGF‑1). All raw material offered is strictly for laboratory research use; it is not intended for application in humans or animals, nor for diagnostic or clinical purposes.
As a GHRH analog, CJC-1295 DAC retains the biologically active N‑terminal 29‑amino acid sequence of endogenous GHRH, with four strategic substitutions to improve resistance to enzymatic degradation. The DAC component consists of a maleimidopropionic acid linker conjugated to a lysine residue, which selectively reacts with the thiol group of cysteine‑34 on circulating albumin. This conjugation effectively creates a stable peptide‑albumin adduct in vitro and in vivo, a property widely exploited in pharmacological research to study prolonged GHRH receptor engagement. Laboratories seeking high‑purity CJC-1295 DAC raw material for sale can rely on rigorously characterized batches suitable for repeatable and reproducible experimentation.
Product Specifications
Each batch of CJC-1295 DAC raw material is subjected to comprehensive analytical testing to ensure consistency and reliability for research protocols. The chemical composition is a GHRH analog peptide covalently linked to the DAC moiety. The full molecular formula and amino acid sequence are provided in the certificate of analysis accompanying each order; researchers may request this documentation from our technical support team. The product is manufactured under controlled conditions and is not exposed to non‑laboratory substances during synthesis or purification.
- Chemical composition: GHRH analog with DAC moiety. Molecular formula and sequence available upon request.
- Purity: ≥98% as determined by reversed‑phase high‑performance liquid chromatography (HPLC) at 220 nm.
- Appearance: White to off‑white lyophilized powder.
- Water content: Less than 5%, measured by Karl Fischer titration.
- Endotoxin level: <1 EU/mg, as confirmed by Limulus Amebocyte Lysate (LAL) gel‑clot or kinetic chromogenic assay.
Chemical Properties
The peptide‑DAC conjugate has a molecular weight of approximately 4000 Daltons. It is readily soluble in distilled water or sterile buffers such as phosphate‑buffered saline (PBS) at concentrations typically employed in bench research. The lyophilized powder demonstrates robust stability when stored under recommended conditions; repeated freeze‑thaw cycles of the lyophilized powder or reconstituted solution can degrade the peptide and should be avoided. Researchers often prepare single‑use aliquots of reconstituted material to preserve structural integrity. The DAC‑albumin binding reaction occurs rapidly in aqueous solutions, and binding characteristics can be studied via size‑exclusion chromatography or mass spectrometry.
Research Applications
CJC-1295 DAC is widely applied in basic and translational laboratory investigations. Its principal utility lies in clarifying the mechanisms governing growth hormone release and the GH/IGF‑1 axis. Because the DAC modification prolongs receptor activation, it serves as a tool for studying sustained endocrine signaling in vitro and in animal models. Researchers may administer the peptide in conjunction with receptor antagonists or signaling inhibitors to dissect intracellular pathways in pituitary somatotrophs or other GH‑responsive cells.
- In vitro studies of GH release pathways: Primary pituitary cell cultures or cell lines are exposed to CJC-1295 DAC to measure GH secretion via ELISA or RIA, allowing exploration of second messenger cascades.
- IGF‑1 modulation in cell culture models: Hepatic and extrahepatic cell models are used to examine the effect of sustained GHRH receptor stimulation on IGF‑1 mRNA expression and protein output.
- In vivo metabolic and muscle research: Rodent models enable assessment of body composition, protein synthesis markers, and metabolic parameters under conditions of extended GHRH receptor activation. Such studies inform fundamental understanding of the GH/IGF‑1 system, but do not translate to therapeutic claims.
The compound is not intended for any diagnostic application, nor may it be used in procedures that directly or indirectly involve human or veterinary subjects outside of strictly controlled laboratory environments.
Storage and Handling
Proper storage and handling are critical to maintaining the integrity of CJC-1295 DAC raw material. Lyophilized vials should be kept in a freezer at −20 °C, protected from light and moisture. Unopened vials stored under these conditions remain stable through the expiration date indicated on the label. After removal from cold storage, allow the vial to reach ambient temperature before opening to prevent condensation.
Reconstitution should be performed with sterile, research‑grade water or buffer. The resulting solution is intended for immediate laboratory use. Due to the absence of preservatives, any unused portion after a single experiment must be discarded. Avoid vortexing vigorously; gentle agitation or swirling is sufficient to achieve dissolution. Do not store reconstituted peptide for later use, as degradation and microbial contamination can occur even under refrigeration.
Packaging Options
We supply CJC-1295 DAC raw material in a range of standard pack sizes to accommodate diverse research requirements. All products are presented in sterile, borosilicate glass vials sealed with bromobutyl rubber stoppers and aluminum flip‑off caps for integrity during transit.
- 1 mg vial
- 5 mg vial
- 10 mg vial
- Bulk quantities (25 mg, 50 mg, 100 mg and above) available upon inquiry
For large‑scale orders placed by research institutions or distribution partners, custom packaging configurations can be arranged. Each vial is labelled with the product name, lot number, net weight, and storage instructions. Certificates of analysis are included with every shipment, documenting purity, water content, and endotoxin levels.
Ordering Information
To obtain current pricing, stock availability, or to request a sample for evaluation, please contact our dedicated sales team. We serve a global client base that includes university laboratories, pharmaceutical companies, and licensed distributors. Bulk discount structures are available for qualifying institutions and repeat orders. Orders are typically processed within 5–7 business days, with dispatch confirmation and tracking details provided upon shipment. For international deliveries, temperature‑controlled packaging (validated cold‑chain shipping) is employed to maintain product stability during transit. Please note that all sales are subject to our standard terms and conditions, which require verification of the buyer’s research‑related credentials.
Frequently Asked Questions
Below are answers to common inquiries from researchers considering the acquisition of CJC-1295 DAC raw material. For further technical questions, our scientific support team can be reached via the contact information provided with your quotation.
Difference Between CJC-1295 and CJC-1295 DAC
CJC-1295 (often referred to as “CJC-1295 without DAC” or Mod GRF 1‑29) is the core 29‑amino acid GHRH analog bearing four substitutions that impart resistance to rapid proteolytic cleavage. It has a relatively short plasma half‑life in research models, typically less than 30 minutes. CJC-1295 DAC incorporates the same peptide sequence but is additionally functionalized with a maleimidopropionic acid linker that covalently attaches to free cysteine residues of serum albumin. In laboratory settings, this DAC modification substantially prolongs the apparent half‑life to hours or days, allowing less frequent administration in animal study designs. This distinction is essential for investigators selecting the appropriate tool for their experimental paradigm.
Human Use Clarification
This product is manufactured for laboratory research only. It is not approved for use in humans, animals, or as a component of any drug, medicine, dietary supplement, or food. Under no circumstances should CJC-1295 DAC raw material be administered outside of a controlled in vitro or in vivo research environment. Our supply agreement strictly prohibits any attempt to repurpose the material for unintended applications.
Reconstitution Guidance for Research
For experimental protocols, researchers typically reconstitute the lyophilized peptide in sterile, high‑purity water or a compatible buffer. The volume added determines the final concentration required for the specific study. After reconstitution, the solution should be used immediately and any remainder discarded. Proper aseptic technique must be observed throughout to avoid contamination of cell cultures or animal models.
Purity Guarantee
Every lot of CJC-1295 DAC raw material undergoes HPLC analysis to confirm purity of ≥98%. In addition, mass spectrometry (ESI‑MS or MALDI‑TOF) verifies molecular weight, and residual counter‑ion content is monitored. The certificate of analysis provided with your order includes batch‑specific results for purity, water content, and endotoxin level. Should any parcel arrive with visible damage, we offer a replacement policy contingent upon timely notification and photographic evidence.
Disclaimer: CJC-1295 DAC raw material is sold strictly for in vitro and in vivo laboratory research use only. It is not intended for human or veterinary application, nor for any diagnostic, therapeutic, or clinical purpose. Purchasers are responsible for compliance with all applicable local, national, and international regulations governing research chemicals.
For research use only. Not for human or veterinary use.
