DSIP: A Research Peptide Overview
Delta Sleep-Inducing Peptide (DSIP) is a synthetic nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. It was first identified in rabbit cerebral blood and has since become a tool in neurobiological research. In laboratory models, scientists study DSIP to understand its interaction with sleep-regulating systems, particularly slow-wave sleep, and its potential influence on stress-response pathways such as the hypothalamic-pituitary-adrenal (HPA) axis. All DSIP supplied is produced exclusively for in vitro research applications; it is not approved or intended for any human or veterinary purpose, and must be handled in accordance with institutional biosafety and research ethics guidelines.
Importance of Certificate of Analysis (COA) in Peptide Research
A Certificate of Analysis (COA) is the foundational document that verifies the identity, purity, and consistency of a research peptide. For DSIP, a reliable COA includes high-performance liquid chromatography (HPLC) data confirming purity typically at or above 98%, alongside mass spectrometry (MS) results that match the theoretical molecular weight and sequence. These analytical data points allow researchers to confirm that the peptide meets specifications before committing to sensitive experiments. Without a batch-specific COA, variables like incomplete synthesis, residual solvents, or peptide content discrepancies can undermine data reproducibility. When selecting a DSIP supplier, the availability of a detailed, transparent COA is therefore not just a convenience—it is an essential component of rigorous experimental design and quality assurance.
Why Choose Our DSIP Supplier Services
Laboratories that partner with us gain a DSIP supplier committed to full analytical traceability. Every shipment is accompanied by a batch-specific COA that details HPLC purity, net peptide content, and mass spectrometry verification. Our synthesis takes place in strictly controlled environments using solid-phase peptide synthesis (SPPS) methods, followed by iterative purification and characterization steps. All batches are tested against established specifications, and quality control documentation is archived for future reference.
We understand that peptide integrity during transit is critical. Lyophilized DSIP is shipped in insulated, temperature-monitored packaging with cold packs to preserve stability. Shipping routes are optimized for speed, and tracking information is provided. Whether you are a university neuroscience department, a contract research organization, or a pharmaceutical R&D team, our process is designed to deliver a consistent product, backed by documentation, that integrates seamlessly into your research workflow.
DSIP Product Specifications
Our standard DSIP product is offered as a lyophilized powder in sealed borosilicate glass vials. The following specifications are verified and reported on each COA:
- Appearance: White to off-white lyophilized cake or powder
- Purity (HPLC): ≥98%
- Molecular Weight (MS): 848.81 g/mol (M+H⁺ observed)
- Molecular Formula: C₃₅H₄₈N₁₀O₁₅
- Net Peptide Content: Determined by quantitative amino acid analysis or elemental analysis
- Solubility: Soluble in sterile water or saline for in vitro research use
- Storage Condition: Store at -20°C immediately upon receipt; protect from light and moisture
- Stability: Lyophilized peptide is stable for months when stored as recommended; reconstituted solutions should be prepared fresh and used promptly
For researchers requiring alternative packaging or specific vial configurations, please contact our technical team. All specifications are validated during release testing and are included in the accompanying COA.
Ordering DSIP for Research Use
Our catalog lists DSIP in standard quantities starting from 1 mg per vial. Bulk options (e.g., 10 mg, 50 mg, or custom aliquots) are available for high-throughput screening or longitudinal studies. Each order is supplied with a comprehensive COA that includes batch number, date of analysis, and the full set of quality control data.
Custom synthesis services are offered for researchers needing labelled or modified DSIP sequences, such as stable isotope-labeled analogues for mass spectrometry-based assays or analogues with specific amino acid substitutions. These projects are managed on a case-by-case basis, and a dedicated project coordinator will provide a feasibility assessment, timeline, and quotation. All custom batches also receive a full COA.
To initiate an order, registered institutional purchasers can submit a request via our secure portal or contact our sales team. We supply to accredited laboratories, biotech enterprises, and authorized distribution partners worldwide. Terms of sale require verification of end-user research intent and compliance with all applicable import regulations.
Frequently Asked Questions
Q: Is DSIP approved for human use?
A: No. DSIP supplied by our organization is strictly a research reagent. It has not received marketing authorization from any regulatory authority for human or veterinary application, and it must only be used in controlled laboratory settings.
Q: How is the purity determined?
A: Purity is assessed by reverse-phase HPLC under validated conditions. The resulting chromatogram is included in the COA, showing the main peak percentage. Mass spectrometry further confirms identity by matching the observed mass/charge ratio to the theoretical value.
Q: Can I request a COA before purchasing?
A: Yes. We provide a representative COA upon inquiry, and for each ordered batch, you will receive the batch-specific COA with the shipment. Pre-purchase review of analytical data is encouraged to ensure suitability for your experimental needs.
Q: What documentation is included with the shipment?
A: Every package contains the COA, a safety data sheet (SDS), and storage instructions. For international orders, necessary customs documentation is prepared to facilitate clearance while respecting the research nature of the product.
Q: How should the lyophilized peptide be reconstituted?
A: For research use, researchers typically reconstitute DSIP in sterile water or a suitable aqueous buffer. The specific solvent and concentration depend on the experimental protocol. Brief vortexing or gentle agitation is recommended, and the reconstituted solution should be used on the same day or aliquoted and stored at -20°C for short-term use, avoiding repeated freeze-thaw cycles.
Research use only: All products referenced in this article are intended solely for laboratory research purposes. They are not designed, approved, or labeled for diagnostic, preventive, therapeutic, or any in vivo human or animal application. Purchasers and end users are responsible for ensuring compliance with all local, national, and international regulations governing the acquisition, handling, and application of research chemicals.
For research use only. Not for human or veterinary use.
