Overview of CJC-1295 Research Peptide
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) developed for advanced laboratory investigations into growth hormone (GH) secretion pathways. As a modified GHRH(1-29) peptide, it incorporates specific amino acid substitutions that confer prolonged biological activity in research models, making it a valuable tool for studying pulsatile hormone release and the GH/IGF-1 axis. Researchers source CJC-1295 raw material for sale to support in vitro cell-based assays and in vivo animal studies that require a stable, long-acting GHRH agonist.
This peptide is designed exclusively as a research chemical. It is supplied in lyophilized form with documented purity and identity, suitable for reconstitution in validated experimental protocols. All applications are confined to controlled laboratory environments; the substance is not manufactured to pharmacopoeial standards and is strictly not for human or veterinary use.
Key Features for Laboratory Research
- Modified GHRH(1-29) analog with extended half-life in scientific models
- Enables investigation of GH release kinetics and feedback mechanisms
- Supplied with comprehensive analytical documentation
- Suitable for academic, pharmaceutical, and industrial research programs
Chemical Properties and Structure
Understanding the molecular identity of CJC-1295 is essential for proper experimental design and reproducibility. The peptide’s structure underlies its research utility, particularly the alterations that influence stability and receptor binding profiles in controlled settings.
Molecular Formula and Weight
CJC-1295 has an approximate chemical formula of C₁₅₂H₂₅₂N₄₄O₄₂. The corresponding molecular weight is around 3376.9 g/mol. These values represent the free base peptide; conjugated forms or salt variants may exhibit slight variations. Researchers should confirm exact specifications with the supplier’s batch-specific Certificate of Analysis.
Amino Acid Sequence and Modifications
The peptide is based on the first 29 amino acids of GHRH, with targeted substitutions that reduce enzymatic degradation and enhance binding to serum albumin in research models. The sequence typically incorporates residues such as Tyr, D-Ala, Gln, and others at critical positions. A reactive moiety often attached for conjugation studies contributes to the extended presence of the peptide in circulation during animal model experiments. Full sequence details are documented in literature and provided by reputable suppliers.
CAS Number and Identification
The commonly cited CAS number for CJC-1295 is 863288-32-0. This identifier should be verified against the material safety data sheet and analytical reports from the source. Variants such as salt forms or specific conjugates may carry distinct CAS registrations; researchers must align the number with the exact product ordered.
Applications de la recherche
CJC-1295 serves as a specialized probe to dissect growth hormone secretory dynamics. Applications span cell culture models, tissue studies, and whole-animal research, always within a non-clinical, non-diagnostic framework.
In Vitro Studies
In pituitary cell lines or recombinant receptor systems, CJC-1295 is used to stimulate GH release and quantify secretory responses. Protocols often measure intracellular signaling intermediates such as cyclic AMP or downstream effectors. These assays help clarify GHRH receptor activation, desensitization, and cross-talk with other regulatory pathways. All work is performed under aseptic, laboratory-grade conditions.
In Vivo Models
Rodent and other animal studies employ CJC-1295 to investigate GH pulsatility, IGF-1 generation, and metabolic readouts. Due to the peptide’s extended half-life in these systems, a single administration can sustain elevated GH levels over prolonged observation periods, facilitating chronic study designs. Typical endpoints include tissue mass, metabolic markers, and expression analysis. Such investigations contribute to fundamental endocrine research without any therapeutic implication.
GH/IGF-1 Axis Investigation
By modulating GHRH receptor activity, researchers can evaluate how altered GH secretion affects the downstream insulin-like growth factor-1 (IGF-1) axis. This is relevant for understanding growth physiology, aging processes, and metabolic regulation in preclinical settings. CJC-1295 provides a reproducible tool to maintain defined GH backgrounds, aiding comparative studies across genotypes or conditions.
Spécifications des produits
Each lot of CJC-1295 raw material released for sale is characterized by rigorous physical and chemical criteria. These parameters ensure consistency and reliability for peer-reviewed research.
Purity and Form
Purity: ≥98% as determined by high-performance liquid chromatography (HPLC). This threshold is standard for research-grade peptides and minimizes interference from related substances.
Form: Lyophilized white to off-white powder. The absence of filler ensures accurate mass measurements for solution preparation.
Packaging Options
- Standard sizes: 1 mg, 5 mg, 10 mg vials
- Bulk and custom quantities: available upon request for scaling experiments or distribution
- Vials are sealed under inert gas to protect integrity during storage and transport
Lignes directrices en matière de solubilité
For research purposes, CJC-1295 is soluble in sterile water or 0.1% acetic acid at approximately 1 mg/mL. Gentle vortexing or sonication may be applied to aid dissolution. Researchers should consult the specific solubility data provided in the Certificate of Analysis, as slight variations can occur between batches.
Assurance qualité
A robust quality framework underpins every unit of CJC-1295 raw material supplied. The goal is to deliver a well-characterized product that meets the documentation expectations of institutional review boards and scientific publishers.
Analytical Testing
Each batch is subjected to HPLC for purity assessment and mass spectrometry for identity confirmation. Additional tests, such as amino acid analysis or peptide content determination, may be performed according to the supplier’s standard operating procedures. Data are recorded and retained for traceability.
Documentation
A Certificate of Analysis (CoA) accompanies every order. The CoA details batch number, test results, date of manufacture, retest date, and storage recommendations. This documentation supports compliance with laboratory record-keeping requirements and facilitates reproducibility in collaborative studies.
Stability and Traceability
Stability studies are conducted under recommended storage conditions to establish shelf life. Raw material synthesis, purification, and packaging are documented from start to finish, enabling full traceability back to the original production lot. This chain of custody is critical for research that demands verified sourcing.
Storage and Handling
Proper handling preserves the structural integrity and activity of CJC-1295, safeguarding experimental outcomes.
Storage Conditions
- Lyophilized peptide: store at -20°C or below, protected from moisture and direct light.
- Short-term stability at 2–8°C may be acceptable for a few days, but long-term storage requires deep-freeze conditions.
- Desiccated environment reduces the risk of hydrolysis.
Reconstitution Recommendations
After reconstitution in sterile water or appropriate buffer (e.g., phosphate-buffered saline, pH 7.4), CJC-1295 solutions should be used promptly for research. If storage of the liquid is necessary, it can be aliquoted and kept at -20°C. Working solutions should be prepared fresh and protected from bacterial contamination.
Aliquoting and Freeze‑Thaw
Avoid repeated freeze-thaw cycles, which can degrade peptide quality. Divide reconstituted material into single-use portions to maintain batch consistency. Each aliquot should be labeled with concentration, date, and storage conditions.
Ordering Information
Supply of CJC-1295 raw material for sale is organized to meet the needs of research institutions, pharmaceutical development teams, and accredited distributors. The procurement process emphasizes transparency, compliance, and logistical reliability.
Global Supply
CJC-1295 research peptide is available for shipment to qualified laboratories worldwide. Researchers are responsible for verifying their local regulations regarding the importation of peptide research materials. An end-use declaration may be required to confirm the exclusively laboratory-based intent.
Lead Times and Custom Orders
Standard orders typically ship within 3–5 business days after confirmation and payment clearance. Custom synthesis, bulk quantities, or specialized packaging can be accommodated with extended lead times. Volume discounts are available for large-scale research programs; inquiry with detailed specifications is recommended.
Shipping and Handling
All consignments are packaged discreetly and securely. Temperature-controlled shipping options (cold packs or dry ice) are used to maintain product integrity during transit. Insulated containers and rapid logistics partners ensure that the lyophilized material arrives in a stable condition. Tracking information is provided after dispatch.
Questions fréquemment posées
- Q: Is CJC-1295 suitable for human use? A: No. This product is strictly for laboratory research use only. It is not approved, manufactured, or tested for human or veterinary applications.
- Q: What purity levels are standard? A: The standard specification is a minimum of 98% purity determined by HPLC. Exacting lot-specific data are listed in the CoA.
- Q: Can I request a Certificate of Analysis? A: Yes. A CoA is included with every shipment. Digital copies can also be provided upon request before or after order confirmation.
- Q: What formulation is the peptide in? A: It is supplied as a lyophilized powder without added carriers. This allows researchers to reconstitute it in the buffer best suited to their protocol.
- Q: Are bulk and custom orders possible? A: Yes. Suppliers can arrange larger quantities, custom vial fills, or alternative packaging. Contact the supplier with your specific requirements to receive a quotation.
À usage exclusivement scientifique : All products described are intended solely for in vitro laboratory research use by qualified professionals. They are not for human or animal use, including veterinary, diagnostic, therapeutic, or any other application. No statements should be construed as a recommendation for non-research purposes. Users must comply with all applicable laws and institutional guidelines.
Réservé à la recherche. Ne pas utiliser chez l'homme ni chez les animaux.
