NAD+ (Nicotinamide Adénine Dinucléotide)

Aperçu du produit

NAD+ (nicotinamide adenine dinucleotide) exists in oxidized (NAD+) and reduced (NADH) forms. The NAD+/NADH ratio is a critical measurement of cellular redox state and metabolic health, typically around 700:1 in the cytoplasm of healthy mammalian tissues. NAD+ is synthesized through de novo pathways from tryptophan or salvage pathways recycling nicotinamide. Age-related decline in NAD+ levels (approximately 50% between ages 30–70) drives reduced cellular function and increased susceptibility to age-related diseases.

Mécanisme d'action

NAD+ serves as a key coenzyme in mitochondrial energy metabolism, converting nutrients into adenosine triphosphate (ATP). It activates sirtuins — a family of proteins involved in energy metabolism, DNA repair, and cellular aging. When cells experience oxidative stress or radiation damage, DNA repair enzymes like PARP consume large amounts of NAD+ to initiate repair and maintain genetic stability.

Principaux avantages

Cellular Energy Production — Essential cofactor for converting nutrients to ATP in mitochondria. Boosting NAD+ enhances mitochondrial function and removes damaged mitochondria, improving overall metabolic efficiency.

Sirtuin Activation & Anti-Aging — Activates sirtuin proteins linked to longevity, energy metabolism, and DNA repair. Helps slow age-related cellular decline.

DNA Repair & Genomic Stability — Powers PARP enzymes for DNA damage repair, maintaining genetic integrity under oxidative stress and environmental damage.

Amélioration cognitive — Suppresses neuroinflammation and improves cognitive performance, supporting long-term brain health.

Références

1. Nelson DL, Cox MM. *Principles of Biochemistry.* 4th ed. 2005.
2. Abdellatif M, et al. NAD+ metabolism in cardiac health, aging, and disease. *Circulation.* 2021;144(22):1795–1817.
3. Conlon NJ. The role of NAD+ in regenerative medicine. *Plast Reconstr Surg.* 2021;150:41S–48S.