Weight Management

Mazdutide

CAS #: 2256232-71-4

Mazdutide is a once-weekly injectable dual GLP-1/glucagon receptor agonist, the first in its class. It reduces appetite and improves blood sugar control through GLP-1 while boosting energy expenditure and fat burning through glucagon activation. Approved in China; clinical trials show up to 14% body weight reduction over 48 weeks and 68% liver fat reduction. Available as solution for injection.

CAS Number 2256232-71-4
Molecular Formula OXM analog
Molecular Weight ~4500 g/mol
Sequence/Composition GLP-1/GCG dual agonist

Available SKUs

Model Specification MOQ
mazdutide-5 5ml 1 vial
mazdutide-10 10ml 1 vial
mazdutide-20 20ml 1 vial
Lead time confirmed with quotation
Batch documents available on request
Specifications confirmed before order

Product Overview

Mazdutide (IBI362/LY3305677), developed by Eli Lilly and Innovent Biologics, is an analog of oxyntomodulin (OXM) that activates both GLP-1 and glucagon receptors. Approved in China as Xinermei in June 2025, it is the first marketed dual GCG/GLP-1 receptor agonist. Clinical data published in Nature, Lancet, and NEJM support its efficacy. Global Phase III trials are underway.

Mechanism of Action

Mazdutide mimics two natural gut hormones simultaneously: GLP-1 (reduces appetite, slows digestion, supports blood sugar control) and glucagon (increases energy expenditure, promotes fat burning, stimulates changes in liver, brain, and adipose tissue). The GLP-1 component counteracts glucagon's glucose-raising effect, creating a net benefit in both weight loss and glycemic control.

Key Benefits

Significant Weight Loss — Clinical trials demonstrate 11–14% body weight reduction over 48 weeks. Dual mechanism produces greater weight loss than GLP-1-only treatments through combined appetite suppression and increased energy expenditure.

Metabolic Health Improvement — Reduces waist circumference, blood sugar levels, cholesterol, and blood pressure beyond weight loss alone.

Liver Health — 10mg dose reduced liver fat by 68% after 32 weeks in MAFLD patients; 70% achieved normal liver fat levels after 48 weeks.

Convenient Once-Weekly Dosing — Single weekly injection provides sustained dual-receptor activation for consistent metabolic support.

References

  1. Ji L, et al. Safety and efficacy of mazdutide (IBI362) in Chinese adults with overweight or obesity. *EClinicalMedicine.* 2022;54:101691.
  2. Guideline for Chronic Weight Management and Clinical Practice of Anti-obesity Medications (2024). *Chin J Endocrinol Metab.* 2024;40(7):545–564.
  3. Jastreboff AM, et al. Tirzepatide once weekly for the treatment of obesity. *N Engl J Med.* 2023.

Technical Support

Our team can assist with product, batch-document and procurement questions during business hours.

Contact Support

OEM Services

Need modifications or larger quantities? Contact us for a custom quote.

Request Custom
CAS Number 2256232-71-4
Molecular Formula OXM analog
Molecular Weight ~4500 g/mol
Sequence/Composition GLP-1/GCG dual agonist
Amino Acids ~30
Form Lyophilized powder
Purity ≥99% by HPLC
Storage -20°C desiccated
What purity level does Mazdutide have, and is a Certificate of Analysis (COA) provided?
Mazdutide is supplied at ≥99% purity as determined by HPLC. Every order includes a lot-specific COA detailing the purity and quality verification.
Can I purchase Mazdutide in bulk or wholesale quantities?
Yes, bulk orders are accepted. Please contact our sales team for volume-based pricing and adjusted minimum order quantities for larger amounts.
Is it possible to obtain a sample of Mazdutide before placing a full order?
Sample availability varies with current stock. Reach out to our sales representatives to inquire about obtaining a sample vial for evaluation purposes.
What are the recommended storage and handling conditions for Mazdutide?
Mazdutide is provided as a lyophilized powder and should be stored at -20°C in a desiccated environment. Upon reconstitution, follow standard peptide handling protocols and avoid repeated freeze-thaw cycles.
How is Mazdutide shipped internationally, and what about customs clearance?
All shipments use cold-chain logistics to maintain product integrity during transit. We prepare necessary documentation, but the buyer is responsible for import permits and customs clearance in the destination country.
What is the typical lead time for a Mazdutide order?
Lead time depends on order size and shipping destination. Standard orders are generally processed within 3–5 business days, while larger or custom orders may require additional preparation time.
Which payment methods are accepted for purchasing Mazdutide?
We accept bank transfers (T/T), major credit cards, and other secure payment options. Specific details are provided during the checkout process.

Related Products

Need OEM or a Custom Configuration?

We offer custom synthesis, modifications, and OEM services. Share your requirements including sequence, purity, quantity, and any special needs—our team will provide a detailed quote.

Request Custom Synthesis Contact Us