Skin & Beauty

Melanotan 2 (MT-2)

CAS #: 121062-08-6

Melanotan II is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that acts as a non-selective melanocortin receptor agonist. It stimulates melanogenesis for UV-free tanning through MC1R activation, enhances libido and erectile function through MC4R activation, and supports appetite suppression and immune modulation. Available as lyophilized powder with ≥99% purity.

CAS Number 121062-08-6
Molecular Formula C50H69N15O9
Molecular Weight 1024.18 g/mol
Sequence/Composition Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Available SKUs

Model Specification MOQ
mt2-5 5ml 1 vial
mt2-10 10ml 1 vial
mt2-20 20ml 1 vial
Lead time confirmed with quotation
Batch documents available on request
Specifications confirmed before order

Product Overview

Melanotan II was developed as a successor to afamelanotide (Melanotan I). It stimulates melanogenesis by activating MC1 receptors on skin cells, producing a darker, more even tan with significantly reduced UV exposure. Its activation of MC4 receptors in the brain drives sexual arousal effects and appetite suppression. The peptide acts on MC1, MC3, MC4, and MC5 receptors with varying potency.

Mechanism of Action

Melanotan II acts as a non-selective melanocortin receptor agonist. MC1R activation stimulates melanocyte pigment production (tanning). MC4R activation in the hypothalamus influences sexual arousal (via dopamine pathways) and appetite regulation. MC3R may contribute to metabolic and sexual effects.

Key Benefits

Tanning with Reduced UV Exposure — Stimulates melanin production for a darker, more even tan while minimizing UV exposure. Beneficial for fair-skinned individuals and those with photosensitivity disorders.

Enhanced Libido & Sexual Function — MC4R activation boosts libido in both men and women and improves erectile function through central melanocortin system stimulation.

Appetite Suppression — MC4R activity suppresses appetite and improves satiety, supporting weight management in conjunction with lifestyle modifications.

Immune Modulation — Modulates inflammatory pathways and cytokine production, with emerging evidence of neuroprotective benefits through BDNF enhancement.

References

  1. Wikberg JE. Melanocortin receptors: new opportunities in drug discovery. *Expert Opin Ther Pat.* 2001;11(1):61–76.
  2. Callaghan DJ. A glimpse into the underground market of melanotan. *Dermatol Online J.* 2018;24(5).
  3. Ezzat S, et al. Melanotan II peptide: metabolism and appetite regulation. *Peptides.* 2008.

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CAS Number 121062-08-6
Molecular Formula C50H69N15O9
Molecular Weight 1024.18 g/mol
Sequence/Composition Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Amino Acids 7
Form Lyophilized powder
Purity ≥99% by HPLC
Storage -20°C desiccated
What is the minimum order quantity (MOQ) for Melanotan 2?
The minimum order is one vial, available in 5ml, 10ml, or 20ml specifications.
How is the purity of Melanotan 2 verified, and do you provide a Certificate of Analysis?
Each batch is tested by HPLC to ensure ≥99% purity. A Certificate of Analysis (COA) is included with every shipment.
Can I obtain a sample of Melanotan 2 for preliminary testing?
Small sample quantities may be available for institutional evaluation; please contact our sales team with your research credentials for sample request terms.
How is Melanotan 2 shipped, and what are the typical lead times?
We ship worldwide under cold-chain conditions to maintain peptide stability. Lead times vary by destination and order volume; current estimates are provided upon order confirmation.
What payment terms are available for B2B orders?
We accept wire transfer and major credit cards for established institutional buyers. Net terms may be arranged after credit approval.
How should I store Melanotan 2 upon receipt?
Store the lyophilized powder at -20°C in a desiccated environment. Reconstituted solutions should be aliquoted and stored at -80°C to preserve activity.
Do you handle customs documentation for international shipments?
Yes, we provide all necessary documentation for customs clearance, including commercial invoices and certificates of analysis. The product is shipped for research use only, which simplifies customs processing in most countries.

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