Anti-Aging

MOTS-c

CAS #: 1627580-64-6

MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded by the MT-RNR1 gene, naturally produced in response to exercise and cellular stress. It activates the AMPK pathway to enhance glucose uptake, fat oxidation, and energy efficiency. Considered an exercise mimetic with applications in metabolic health, anti-aging, and longevity research. Available as lyophilized powder with ≥98% purity.

CAS Number 1627580-64-6
Molecular Formula C101H152N28O25S2
Molecular Weight 2174.58 g/mol
Sequence/Composition MRWQEMGYIFYPRKLR

Available SKUs

Model Specification MOQ
motsc-5 5ml 1 vial
motsc-10 10ml 1 vial
motsc-20 20ml 1 vial
Lead time confirmed with quotation
Batch documents available on request
Specifications confirmed before order

Product Overview

MOTS-c (mitochondrial ORF of the 12S rRNA type-C) is a naturally occurring peptide encoded by mitochondrial DNA with the amino acid sequence MRWQEMGYIFYPRKLR. It mediates mitochondrial-nuclear communication by translocating to the cell nucleus under exercise or stress conditions. Levels decline naturally with age, correlating with increased susceptibility to metabolic and age-related conditions. Upregulated by exercise, it is classified as an exercise mimetic.

Mechanism of Action

MOTS-c activates the AMP-activated protein kinase (AMPK) pathway, a key regulator of cellular metabolism and homeostasis. This stimulates glucose uptake and fat oxidation, primarily in skeletal muscle. It translocates to the cell nucleus to mediate mitochondrial-nuclear communication, coordinating multiple mitochondrial functions and maintaining cellular homeostasis.

Key Benefits

Metabolic Optimization — Improves insulin sensitivity and glucose regulation. Supports fat loss and metabolic efficiency through AMPK-mediated fat oxidation and glucose uptake.

Exercise Mimetic — Replicates key metabolic benefits of exercise at the cellular level. Enhances muscle function, endurance, and physical performance. Promotes muscle differentiation and protects against muscle wasting.

Anti-Aging & Longevity — Protective effects against age-related decline in metabolism, bone density, and cellular function. Supports osteoblast proliferation and mineralization while inhibiting osteoclast production.

Cognitive Support — Associated with improved memory and cognitive function, including enhanced object/location recognition and memory consolidation.

Cellular Repair — Reduces inflammation and oxidative stress, supports mitochondrial function in skin cells, and may enhance healing outcomes after aesthetic procedures.

References

  1. Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. *Cell Metab.* 2015;21(3):443–454.
  2. Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline. *Nat Commun.* 2021;12:470.
  3. Wan W, et al. Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging. *J Transl Med.* 2023;21:36.

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CAS Number 1627580-64-6
Molecular Formula C101H152N28O25S2
Molecular Weight 2174.58 g/mol
Sequence/Composition MRWQEMGYIFYPRKLR
Amino Acids 16
Form Lyophilized powder
Purity ≥99% by HPLC
Storage -20°C desiccated
What is the purity of MOTS-c and do you provide a Certificate of Analysis (COA)?
MOTS-c is supplied with a purity of ≥99% as determined by HPLC. Each shipment includes a lot-specific Certificate of Analysis (COA) detailing purity, mass spectrometry data, and other relevant quality metrics.
Is MOTS-c available in bulk or wholesale quantities?
Yes, bulk and wholesale orders are available. Please contact our sales team with your required quantity and specifications for a tailored quotation.
What is the minimum order quantity (MOQ) for MOTS-c?
The MOQ is 1 vial per specification. Available vial sizes are 5ml, 10ml, and 20ml under SKUs motsc-5, motsc-10, and motsc-20 respectively.
Can I obtain a sample of MOTS-c for evaluation?
Sample availability may be limited. Please direct your request to our sales department for current sample policies and shipping feasibility to your location.
How should MOTS-c be stored and handled?
MOTS-c should be stored at -20°C in a desiccated environment. The lyophilized powder is stable under these conditions. Reconstitution should be performed using appropriate solvents and sterile techniques, and aliquots should be stored at -20°C or lower to maintain integrity.
What are the shipping conditions for MOTS-c?
MOTS-c is shipped via cold chain using insulated packaging and temperature monitoring to ensure product stability during transit. Shipping logistics vary by destination; please confirm with our team for your specific region.
What payment terms do you accept for MOTS-c orders?
We support multiple payment methods including wire transfer, credit card, and other major options. Payment terms may be negotiated for bulk orders. Please contact our billing department for detailed information.

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