Peptide Blends

Cagrilintide + Semaglutide Blend (CagriSema)

CagriSema is an investigational once-weekly combination of cagrilintide (amylin/calcitonin receptor agonist) and semaglutide (GLP-1 receptor agonist), developed by Novo Nordisk. Their complementary mechanisms amplify appetite reduction, energy expenditure, and glycemic control beyond monotherapy. Phase II trials show 15.6% body weight reduction over 32 weeks with improved HbA1c. FDA approval pending. Available as solution for injection.

Available SKUs

Model Specification MOQ
cagrisema-5 5ml 1 vial
cagrisema-10 10ml 1 vial
cagrisema-20 20ml 1 vial
Lead time confirmed with quotation
Batch documents available on request
Specifications confirmed before order

Product Overview

Developed as a potential successor to Ozempic, Mounjaro, and Wegovy, CagriSema combines two mechanisms: cagrilintide promotes satiety, slows gastric emptying, and suppresses postprandial glucagon release via amylin/calcitonin receptors; semaglutide enhances glucose-dependent insulin secretion, suppresses appetite via CNS pathways, and delays gastric emptying via GLP-1 receptors. Phase II weight loss averaged 15.6% after 32 weeks, comparable to tirzepatide. Multiple Phase III trials are ongoing including populations with kidney disease.

Mechanism of Action

Cagrilintide and semaglutide act on complementary neuroendocrine circuits. Cagrilintide mimics amylin to promote satiety and suppress glucagon. Semaglutide activates GLP-1 receptors for insulin secretion and appetite suppression. Together, their converging mechanisms amplify appetite regulation, energy intake reduction, and glycemic improvements exceeding monotherapy results.

Key Benefits

Superior Weight Loss — Synergistic weight reduction up to 15–17% over 20–32 weeks, exceeding either component alone. Comparable efficacy to tirzepatide.

Enhanced Glycemic Control — Significantly improved HbA1c compared to cagrilintide alone. Complementary insulin and glucagon regulation for comprehensive blood sugar management.

Favorable Safety Profile — Side effects are mild to moderate, mainly gastrointestinal (nausea, vomiting, diarrhea), diminishing over time. No instances of severe hypoglycemia in trials.

Once-Weekly Convenience — Single weekly injection delivers dual-receptor activation for sustained metabolic benefits with minimal treatment burden.

References

  1. Enebo LB, et al. Safety and pharmacodynamics of cagrilintide with semaglutide 2.4 mg for weight management. *Lancet.* 2021;397(10286):1736–1748.
  2. Wadden TA, et al. Lifestyle modification approaches for the treatment of obesity in adults. *Am Psychol.* 2020;75:235–251.
  3. Kollewe J. Wegovy and Ozempic owner dealt blow as next-gen weight-loss drug is labelled 'obsolete'. *The Guardian.* 2026.

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Our team can assist with product, batch-document and procurement questions during business hours.

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OEM Services

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Is this product available in bulk quantities?
Yes, we can accommodate bulk orders. The minimum order quantity is 1 vial per SKU, and larger quantities may be eligible for volume pricing. Please contact us for a customized quote.
What is the purity level and do you provide a Certificate of Analysis (COA)?
This Cagrilintide and Semaglutide blend is ≥99% pure by HPLC. A Certificate of Analysis is included with every order to confirm the product’s specifications.
Can I request a sample for evaluation?
Sample availability is subject to current stock and our sampling policy. Please reach out to our sales team to discuss whether a sample can be provided for your research needs.
What are the typical lead times for orders?
Lead times depend on order size, destination, and current production schedules. Generally, orders are processed promptly after payment confirmation. Contact us for an estimated delivery timeline.
How is the product shipped, and do you handle customs?
We ship worldwide using validated cold-chain logistics to preserve product integrity. We supply necessary documentation for customs clearance, but the buyer is responsible for verifying import regulations and any duties in their country.
What payment terms are accepted?
We accept various payment methods, which are negotiated during the quotation process. Terms may vary depending on the order size and client agreement.
What is the recommended storage condition for this blend?
Store lyophilized powder at -20°C in a desiccated environment. Avoid repeated freeze-thaw cycles to maintain stability and purity.

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