Reproductive Health

HCG (Human Chorionic Gonadotropin)

CAS #: 9002-61-3

HCG (Human Chorionic Gonadotropin) is a hormone naturally produced during pregnancy by trophoblast cells. Structurally similar to LH, HCG is used clinically to treat infertility by stimulating ovulation in women and testosterone production in men. It also serves as a tumor marker for germ cell cancers and has applications in hormonal balance and weight management. Available as lyophilized powder.

CAS Number 9002-61-3
Molecular Formula Glycoprotein
Molecular Weight ~36,700 g/mol
Sequence/Composition Glycoprotein (237 amino acids)

Available SKUs

Model Specification MOQ
hcg-5 5ml 1 vial
hcg-10 10ml 1 vial
hcg-20 20ml 1 vial
Lead time confirmed with quotation
Batch documents available on request
Specifications confirmed before order

Product Overview

HCG is a hormone primarily produced during pregnancy, responsible for maternal recognition of pregnancy and detectable by pregnancy tests. HCG levels double every 2–3 days during early pregnancy, peaking around 6–8 weeks. Beyond pregnancy, HCG has significant clinical applications: certain tumors produce HCG (making it a valuable tumor marker), and its structural similarity to luteinizing hormone (LH) enables it to stimulate testosterone production and spermatogenesis.

Mechanism of Action

HCG regulates expression of EG-VEGF (endocrine gland-derived vascular endothelial growth factor) and its receptors PROKR1 and PROKR2. Due to structural similarity to LH, HCG acts as an LH agonist, stimulating testosterone production in Leydig cells and directly promoting spermatogenesis.

Key Benefits

Tumor Marker Utility — β-HCG is widely used in oncology for diagnosing and monitoring germ cell tumors, choriocarcinoma, and other malignancies. Combined with alpha-fetoprotein (AFP), it provides high sensitivity and specificity. Normal reference range for men: 0–5 mIU/mL.

Hormonal Balance Support — Stimulates endogenous testosterone production by mimicking LH, helping restore hormonal equilibrium in age-related decline. Addresses root causes rather than symptoms, improving physical vitality, emotional resilience, and cognitive function.

Fertility Enhancement — Stimulates Leydig cells to produce testosterone essential for spermatogenesis. Supports sperm maturation and motility, increasing conception likelihood. Integrated into treatment protocols for hypogonadotropic hypogonadism.

Weight Management Support — May act on the hypothalamus to regulate appetite and mobilize adipose tissue stores when combined with structured dietary programs. Promotes utilization of stored fat while preserving lean muscle mass.

References

  1. Gregory JJ, Finlay JL. Alpha-fetoprotein and beta-human chorionic gonadotropin: their clinical significance as tumour markers. *Drugs.* 1999;57(4):463–467.
  2. Chan CC, et al. Bioavailability of hCG after intramuscular or subcutaneous injection in obese and non-obese women. *Hum Reprod.* 2003;18(11):2294–2297.
  3. Butler SA, et al. The increase in bladder carcinoma cell population induced by the free beta subunit of human chorionic gonadotrophin. *Br J Cancer.* 2000;82(9):1553–1556.

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CAS Number 9002-61-3
Molecular Formula Glycoprotein
Molecular Weight ~36,700 g/mol
Sequence/Composition Glycoprotein (237 amino acids)
Amino Acids 237
Form Lyophilized powder
Purity ≥99% by HPLC
Storage -20°C desiccated
What bulk quantities are available for HCG?
We offer HCG in vial sizes of 5ml, 10ml, and 20ml. For larger bulk purchases, please contact our sales team for tailored quotations and availability.
Is a Certificate of Analysis (COA) provided with HCG orders?
Yes, a COA is included with every order, detailing the purity, identity, and other quality parameters of the specific batch. Our HCG is ≥99% pure by HPLC.
Can I request a sample before placing a bulk order?
Sample availability may be limited. Please inquire with our customer support regarding the possibility of obtaining a small test sample for your research evaluation.
What are the typical lead times for HCG shipments?
Lead times vary based on order size and destination. We aim to process orders promptly; please contact us for an estimated delivery schedule for your specific request.
How is HCG shipped, and do you handle customs?
HCG is shipped lyophilized under cold-chain conditions to ensure stability. We handle export documentation, but customers are responsible for import customs clearance and any applicable duties.
What payment terms do you accept for international orders?
We accept payment via bank transfer (TT), letter of credit (LC) for large orders, and other methods. Please discuss with our team to arrange suitable terms.
What are the recommended storage conditions for HCG?
Lyophilized HCG should be stored at -20°C in a desiccated environment. For reconstitution and handling, please follow standard laboratory protocols.

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