Reproductive Health

KissPeptin-10

CAS #: 374675-21-5

Kisspeptin-10 is a hypothalamic neuropeptide that regulates the reproductive system by stimulating GnRH secretion, which triggers LH and FSH release from the pituitary gland. It supports natural testosterone production, prevents testicular atrophy during TRT, and helps maintain fertility. Studied for reproductive disorders including hypothalamic amenorrhea and PCOS, with emerging anti-cancer properties. Available as lyophilized powder with ≥98% purity.

CAS Number 374675-21-5
Molecular Formula C50H69N13O11
Molecular Weight 1042.17 g/mol
Sequence/Composition YNWNSFGLRF-NH2

Available SKUs

Model Specification MOQ
kisspeptin-5 5ml 1 vial
kisspeptin-10 10ml 1 vial
kisspeptin-20 20ml 1 vial
Lead time confirmed with quotation
Batch documents available on request
Specifications confirmed before order

Product Overview

Kisspeptin-10, originally named Metastin for its metastasis-suppressing properties, is the smallest endogenous kisspeptin fragment that binds to the KISS1R receptor with similar affinity to the full-length kisspeptin-54. It stimulates the hypothalamic-pituitary-gonadal (HPG) axis, making it essential for reproductive hormone regulation. Particularly valuable for men on testosterone replacement therapy to maintain endogenous testosterone production and prevent testicular atrophy.

Mechanism of Action

Kisspeptin-10 activates KISS1R receptors in the pituitary gland, triggering a cascade that releases GnRH, which stimulates LH and FSH secretion. LH stimulates Leydig cells for testosterone production; FSH supports spermatogenesis. This mechanism mimics the combined actions of clomiphene and HCG, maintaining the natural HPG axis feedback loop.

Key Benefits

Natural Testosterone Support — Stimulates endogenous testosterone production through the HPG axis, offering a physiological approach to hormonal optimization without suppressing natural production.

Testicular Atrophy Prevention — Maintains LH levels during testosterone replacement therapy, preventing the testicular shrinkage commonly associated with exogenous testosterone use.

Fertility Regulation — Supports reproductive function in both men and women. Studied for treating hypothalamic amenorrhea, PCOS, and idiopathic hypogonadotropic hypogonadism.

Anti-Cancer Potential — Originally named Metastin for its ability to inhibit cancer cell migration and invasion, with emerging research in melanoma and breast cancer metastasis suppression.

References

  1. Gottsch ML, et al. From KISS1 to kisspeptins: an historical perspective. *Peptides.* 2009;30:4–9.
  2. Constantin S, et al. Kisspeptin-10 facilitates a plasma membrane-driven calcium oscillator in GnRH-1 neurons. *Endocrinology.* 2009;150:1400–1412.
  3. Topaloglu AK, et al. Inactivating KISS1 mutation and hypogonadotropic hypogonadism. *N Engl J Med.* 2012;366:629–635.

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CAS Number 374675-21-5
Molecular Formula C50H69N13O11
Molecular Weight 1042.17 g/mol
Sequence/Composition YNWNSFGLRF-NH2
Amino Acids 10
Form Lyophilized powder
Purity ≥99% by HPLC
Storage -20°C desiccated
What is the purity of Kisspeptin-10 and is a Certificate of Analysis provided?
The purity is ≥99% by HPLC. A Certificate of Analysis (COA) is included with every order to verify batch-specific quality data.
Is Kisspeptin-10 available in bulk quantities for research institutions?
Yes, we offer bulk and wholesale options. Please contact our sales team for volume pricing and availability.
Can I request a small sample before placing a larger order?
Sample vials may be available for qualified research institutions. Inquire with our team about sample requests.
What are the recommended storage conditions for Kisspeptin-10?
Store at -20°C in a desiccated environment. The lyophilized powder should remain stable when handled properly.
How does your cold-chain shipping ensure product integrity during international transit?
We use validated cold-chain packaging to maintain low temperatures. Shipping documentation is handled for customs clearance.
What are your payment terms and accepted methods for international orders?
We accept bank transfers and other secure payment methods. Terms may include prepayment or partial payment, depending on the order size and customer relationship.
What is the typical lead time for processing and shipping a Kisspeptin-10 order?
Lead time is generally 1-3 business days after order confirmation, but may vary for bulk orders. We provide tracking upon dispatch.

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