Brain & Cognitive

Pinealon

CAS #: 1206780-50-2

Pinealon (EDR peptide) is a synthetic tripeptide (Glu-Asp-Arg) derived from the neuropeptide complex Cortexin. It functions as a peptide bioregulator with neuroprotective, sleep-regulatory, and geroprotective properties. Its mechanism involves regulating gene expression, suppressing oxidative stress, stabilizing mitochondria, and supporting serotonin synthesis. Available as lyophilized powder with ≥98% purity.

CAS Number 1206780-50-2
Molecular Formula C13H24N6O8
Molecular Weight 392.36 g/mol
Sequence/Composition Glu-Asp-Arg

Available SKUs

Model Specification MOQ
pinealon-5 5ml 1 vial
pinealon-10 10ml 1 vial
pinealon-20 20ml 1 vial
Lead time confirmed with quotation
Batch documents available on request
Specifications confirmed before order

Product Overview

Pinealon belongs to a class of ultra-short peptide bioregulators developed in Russia. Its simpler tripeptide structure provides higher stability, better tissue penetration, and lower immunogenic risk compared to its parent compound Cortexin. Pinealon interacts directly with the cell genome, regulating gene expression and modulating cellular processes including ROS accumulation, cell cycle progression, and neuronal repair.

Mechanism of Action

Pinealon regulates mRNA expression associated with neuronal repair, suppresses oxidative stress and free radical damage, stabilizes mitochondria under metabolic load, supports melatonin-associated circadian balance, and modulates apoptosis-related signaling pathways. It also promotes 5-tryptophan hydroxylase expression through epigenetic modifications, supporting serotonin synthesis.

Key Benefits

Neuroprotection — Reduces reactive oxygen species accumulation and necrotic cell death in brain tissue. Supports neuronal survival by suppressing oxidative stress and stabilizing mitochondrial function.

Sleep Regulation — Influences the sleep-wake cycle by supporting pineal gland function and circadian rhythm normalization. May mitigate disruptions from shift work and jet lag.

Cognitive Enhancement — Supports both short-term and long-term memory through neural pathway optimization. Enhances learning retention, particularly beneficial for learning-intensive tasks.

Cellular Anti-Aging — Modulates irisin expression in muscle cells (supporting telomere protection), decelerates cellular aging markers in the CNS, and promotes fat oxidation pathways.

References

  1. Meshchaninov VN, et al. Effect of synthetic peptides on aging of patients with chronic polymorbidity. *Advances in Gerontology.* 2015;28(1):62–67.
  2. Karantysh GV, et al. Effect of Pinealon on learning and expression of NMDA receptor subunit genes in rats with experimental diabetes. *Neurochem J.* 2020;14(3):314–320.
  3. Childs BG, et al. Senescent cells: an emerging target for diseases of ageing. *Nat Rev Drug Discov.* 2017;16:718–735.

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CAS Number 1206780-50-2
Molecular Formula C13H24N6O8
Molecular Weight 392.36 g/mol
Sequence/Composition Glu-Asp-Arg
Amino Acids 3
Form Lyophilized powder
Purity ≥99% by HPLC
Storage -20°C desiccated
What is the purity of Pinealon and is a Certificate of Analysis provided?
Pinealon is supplied with ≥99% purity by HPLC. Every order includes a Certificate of Analysis (COA) verifying the product’s identity and purity.
In what form is Pinealon available?
Pinealon is provided as a lyophilized powder to ensure stability during storage and shipping.
How should Pinealon be stored?
For long-term storage, keep the lyophilized powder at -20°C in a desiccated environment. Avoid repeated freeze-thaw cycles.
Do you offer bulk or wholesale quantities of Pinealon?
Yes, we support bulk orders. Please contact our sales team for volume pricing and availability.
Can I request a sample before placing a larger order?
Small trial orders are available for evaluation. Reach out to our team to discuss sample availability and terms.
What are the shipping conditions and delivery lead times for Pinealon?
We ship Pinealon via cold-chain logistics to maintain product integrity. Standard lead time is typically 3-5 business days after order confirmation; contact us for exact timelines to your destination.
What payment terms do you accept for international orders?
We accept wire transfer and other standard B2B payment methods. Terms are negotiable for larger or recurring orders. Please inquire with our billing department.

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