Brain & Cognitive

Selank

CAS #: 129954-34-3

Selank is a synthetic neurocognitive peptide analog of the natural immunomodulatory peptide tuftsin. It manages anxiety and mood disorders while enhancing cognition and neuroprotection without sedation or dependency risks. Its mechanism involves serotonin/dopamine/noradrenaline modulation, GABAergic anxiolytic activity, enkephalin protection, and immunomodulatory effects. Approved in Russia for generalized anxiety disorder. Available as nasal spray or lyophilized powder with ≥98% purity.

Available SKUs

Model Specification MOQ
selank-5 5ml 1 vial
selank-10 10ml 1 vial
selank-20 20ml 1 vial
Lead time confirmed with quotation
Batch documents available on request
Specifications confirmed before order

Product Overview

Selank (TP-7) was developed at the Institute of Molecular Genetics as a modified analog of tuftsin, a natural peptide from immunoglobulin G. While tuftsin primarily modulates immune function, Selank extends these properties to include anxiolytic and nootropic benefits. Approved in Russia in 2009 for generalized anxiety disorder, it offers benzodiazepine-comparable anxiety reduction without amnesia, withdrawal, or dependence.

Mechanism of Action

Selank works through two primary mechanisms: (1) Cognition enhancement via modulation of noradrenaline, serotonin, and dopamine levels; (2) Anxiolytic effects via GABAergic activity — modulating GABA-A receptors to increase inhibitory action on neuronal excitability. It also inhibits enkephalin-degrading enzymes, providing natural pain relief, and regulates BDNF expression in the hippocampus.

Key Benefits

Anxiety Reduction Without Sedation — Comparable to benzodiazepines for GAD but without sedation, cognitive impairment, amnesia, or addiction. A 2008 clinical trial in 30 GAD patients confirmed similar anxiolytic effects plus cognitive enhancement.

Brain Protection — Supports BDNF expression in the hippocampus, showing promise in countering alcohol-related brain damage and supporting neural repair.

Pain & Inflammation Relief — Inhibits enzymes that degrade enkephalins (natural pain-relieving peptides), providing analgesic and anti-inflammatory benefits.

Immune Modulation — Demonstrates antiviral properties and immune-regulating effects. Shown to reduce depression in human trials through immune modulation pathways.

References

  1. Inozemtseva LS, et al. Intranasal administration of Selank regulates BDNF expression in the rat hippocampus. *Doklady Biol Sci.* 2008;421:241–243.
  2. Holland N, et al. The role of noradrenaline in cognition and cognitive disorders. *Brain.* 2021;144(8):2243–2256.
  3. España RA, et al. Norepinephrine at the nexus of arousal, motivation and relapse. *Brain Res.* 2016;1641(Pt B):207–216.

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What is the purity of Selank and is a COA provided?
Selank is supplied with a purity of ≥99% as measured by HPLC. Every order includes a detailed Certificate of Analysis (COA) that confirms the batch-specific purity and identity of the peptide.
Is Selank available in bulk quantities and what are the MOQs?
Yes, bulk orders are accepted. Our standard SKUs include 5ml, 10ml, and 20ml vials, each with a minimum order quantity of one vial. For larger requirements, please reach out to our sales team for customized volume pricing and availability.
Can I obtain a sample for initial evaluation?
The minimum order quantity of one vial can serve as a sample for initial research. We do not typically offer free samples, but a single vial purchase allows you to evaluate the product’s quality before committing to larger quantities.
What are the shipping conditions and how is Selank stored?
Selank is shipped as a lyophilized powder using cold-chain logistics to preserve integrity. Upon receipt, it should be stored at -20°C in a desiccated environment. Proper storage is essential for maintaining stability.
What payment methods do you accept and what is the lead time?
We accept wire transfers and major credit cards. Standard lead time is 3-5 business days after payment confirmation, though actual delivery may vary depending on your location and customs processing.
How are customs and import regulations handled for international orders?
We provide standard documentation declaring the product for research use only. It is the customer’s responsibility to ensure compliance with their country’s import regulations. We support customs clearance with necessary paperwork such as a commercial invoice and packing list.
What is the molecular sequence and composition of Selank?
Selank consists of the heptapeptide sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, corresponding to a tuftsin analog. Its molecular formula is C33H57N11O9 with a weight of 751.87 g/mol.

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