Brain & Cognitive

Semax

CAS #: 80714-61-0

Semax is a synthetic nootropic peptide analog of ACTH(4-10), developed in Russia. It delivers neurotrophic benefits without hormonal side effects by modulating dopamine/serotonin systems, increasing BDNF, and regulating the HPA axis. Clinically enhances memory, attention, and cognitive function while reducing anxiety and supporting stroke recovery. Available as nasal spray or lyophilized powder with ≥98% purity.

Available SKUs

Model Specification MOQ
semax-5 5ml 1 vial
semax-10 10ml 1 vial
semax-20 20ml 1 vial
Lead time confirmed with quotation
Batch documents available on request
Specifications confirmed before order

Product Overview

Semax mimics only a fragment of ACTH, delivering neurotrophic effects (neuron survival and growth support) without the endocrine effects of full-length ACTH (cortisol/androgen release). Developed in the 1980s by the Institute of Molecular Genetics of the Russian Academy of Sciences, it has been extensively studied for cognitive enhancement, neuroprotection, and mood regulation.

Mechanism of Action

Semax modulates dopaminergic and serotonergic systems for mood regulation and cognition. It increases Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus and prefrontal cortex, supporting neuron survival, synaptogenesis, and neural plasticity. It regulates the HPA axis to normalize cortisol output after chronic stress. Additionally, it improves cerebral blood flow and provides antioxidant protection for neural cells.

Key Benefits

Cognitive Enhancement — Significant improvement in cognitive function demonstrated in clinical studies. Enhances brain Default Mode Network activity. Potential ADHD treatment without typical stimulant side effects.

Mood Regulation — Anti-depressant and anti-anxiety effects through serotonin and BDNF modulation. Improves mood in patients with motor neuron disease. Reduces anxiety without sedation.

Neurotrophic Support — Elevates BDNF in key brain regions, promoting neuron survival, synaptic plasticity, and stress resilience. Supports learning, memory, and neural circuit repair.

HPA Axis Normalization — Reduces post-chronic-stress cortisol overflow, restoring hormonal balance and indirectly supporting reproductive health by reducing cortisol's suppression of GnRH.

References

  1. Pae CU. Therapeutic possibility of Semax for depression. *CNS Spectr.* 2008;13(1):20–21.
  2. Liu W, et al. Brain-derived neurotrophic factor and its potential therapeutic role in stroke comorbidities. *Neural Plast.* 2020;2020:1969482.
  3. Westbrook A, Braver TS. Dopamine does double duty in motivating cognitive effort. *Neuron.* 2016;89(4):695–710.

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Our team can assist with product, batch-document and procurement questions during business hours.

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Is a Certificate of Analysis (COA) provided with Semax orders?
Yes, every order of Semax includes a batch-specific Certificate of Analysis (COA) confirming the product's purity and identity.
What purity level does your Semax peptide achieve?
Our Semax lyophilized powder is tested to be ≥99% pure by HPLC, ensuring high consistency and reliability for laboratory research.
How should Semax be stored for long-term stability?
Store the lyophilized powder at -20°C in a desiccated environment. Protect from light and avoid repeated freeze-thaw cycles to maintain integrity.
Do you offer bulk or wholesale pricing for Semax?
Yes, we accommodate bulk orders. Please contact our sales team to discuss volume-based pricing and larger minimum order quantities beyond the single vials listed on the website.
How is Semax shipped internationally, and what documentation is provided?
We ship Semax via cold-chain logistics to preserve product quality. All shipments include a commercial invoice, Certificate of Analysis, and any required export documentation. The buyer is responsible for confirming import regulations and handling any duties or taxes.
Are samples of Semax available for research evaluation?
Small sample quantities may be available upon request subject to our sample policy. Contact our team to discuss your specific requirements and shipping arrangements.

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