Recovery & Healing

VIP (Vasoactive Intestinal Peptide)

CAS #: 40077-57-4

VIP is a 28-amino-acid peptide hormone acting as both hormone and neurotransmitter. It induces vasodilation, stimulates heart contractility, relaxes smooth muscles, modulates gastrointestinal function, influences circadian rhythms, and demonstrates anti-inflammatory and immunomodulatory properties. Studied for autoimmune conditions, brain health, and infection control. Available as lyophilized powder with ≥95% purity.

Available SKUs

Model Specification MOQ
vip-5 5ml 1 vial
vip-10 10ml 1 vial
vip-20 20ml 1 vial
Lead time confirmed with quotation
Batch documents available on request
Specifications confirmed before order

Product Overview

VIP is produced in the gut, pancreas, and hypothalamus. It stimulates heart contractions, causes vasodilation, lowers blood pressure, increases glycogen breakdown, relaxes smooth muscle in the trachea, stomach, and gallbladder, and modulates GI motility and secretion. In the brain, it affects blood flow, melatonin production, and circadian rhythm.

Mechanism of Action

VIP binds to VPAC1 and VPAC2 receptors, triggering G-alpha-mediated signaling cascades that increase cAMP and PKA activity. PKA then activates transcriptional factors including CREB, and regulates molecular clock genes Per1 and Per2 for circadian rhythm modulation. VIP is co-released with GABA, influencing neural synchronization.

Key Benefits

Anti-Inflammatory — Decreases most inflammatory cytokines. Shows anti-inflammatory effects in arthritis models and may support immune tolerance by suppressing Th1 and promoting Th2 responses.

Immune Balance — Studied for autoimmune/inflammatory diseases including rheumatoid arthritis, ulcerative colitis, multiple sclerosis, Parkinson's disease, and Crohn's disease.

Brain Health — Neuroprotective properties that increase cellular resistance against oxidative stress, support neuronal survival, and exert anti-anxiety effects.

Antimicrobial Activity — Displays antimicrobial properties against various pathogens including Streptococcus, E. coli, Pseudomonas, and Candida in laboratory studies.

Metabolic Regulation — Influences blood glucose, insulin, and leptin levels. VIP-deficient models show elevated glucose and enhanced sweet taste preference linked to leptin resistance.

References

  1. Vosko AM, et al. Vasoactive intestinal peptide and the mammalian circadian system. *Gen Comp Endocrinol.* 2007;152(2–3):165–175.
  2. Maduna T, Lelievre V. Neuropeptides shaping the CNS development: spatiotemporal actions of VIP and PACAP. *J Neurosci Res.* 2016;94(12):1472–1487.
  3. Kingsbury MA. New perspectives on VIP as a widespread modulator of social behavior. *Curr Opin Behav Sci.* 2015;6:139–147.

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What is the purity of VIP (Vasoactive Intestinal Peptide) and is a Certificate of Analysis provided?
VIP is supplied with a purity of ≥99% as determined by HPLC. A Certificate of Analysis (COA) is included with every order, detailing the batch-specific results.
What are the available vial sizes and minimum order quantity?
VIP is available in 5ml, 10ml, and 20ml vials. The minimum order quantity is one vial.
How should VIP be stored to maintain stability?
The lyophilized powder should be stored at -20°C in a desiccated environment. Avoid repeated freeze-thaw cycles after reconstitution.
Do you offer international shipping and how are customs handled?
Yes, we offer cold-chain shipping worldwide. All shipments are accompanied by documentation indicating the product is for research use only. The buyer is responsible for ensuring compliance with any import regulations in their country.
Is it possible to obtain a sample before placing a larger order?
Since the minimum order quantity is one vial, a single vial can serve as a sample. For larger evaluations, please contact us to discuss your requirements.
What payment terms are available?
We accept bank transfers and major credit cards. Terms may vary based on order volume and buyer location. Our sales team can provide details specific to your inquiry.
What is the lead time for VIP orders?
Lead time depends on current stock levels and order volume. In-stock items typically ship within a few business days. Custom or large-volume orders may require additional time; contact us for a current estimate.

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